Pharmacokinetics of Tamoxifen and Its Major Metabolites and the Effect of the African Ancestry Specific CYP2D6*17 Variant on the Formation of the Active Metabolite, Endoxifen
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DOI: 10.3390/jpm13020272
Abstract: Tamoxifen (TAM) is widely used in the treatment of hormone receptor-positive breast cancer. TAM is metabolized into the active secondary metabolite endoxifen (ENDO), primarily by CYP2D6. We aimed to investigate the effects of an African-specific… read more here.
Keywords: cyp2d6 variant; cyp2d6; specific cyp2d6; metabolite endoxifen ... See more keywords