Rapid Manufacture and Isolation of Highly Viable Interferon-γ Expressing Virus-Specific T Cells: Validation Results for the Virus-Specific Cytotoxic T-Lymphocyte Consortium for Refractory EBV, CMV, and Adenovirus Infections
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.589
Abstract: Background Children and young adults who develop treatment-refractory infection with EBV, CMV, and/or adenovirus (AdV) after allogeneic hematopoietic stem cell transplant (allo-HSCT) have a dismal prognosis (≥90% mortality). Adoptive transfer of ex-vivo expanded virus-specific cytotoxic… read more here.
Keywords: specific cytotoxic; cmv adenovirus; virus specific; specific cells ... See more keywords
Outcomes and Challenges of Manufacturing Virus-Specific Cytotoxic T-lymphocytes Using IFN-gamma Cytokine Capture System
Sign Up to like & getrecommendations! Published in 2020 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2020.03.092
Abstract: Background & Aim Background Viral infection/reactivation after allogeneic hematopoietic stem cell (HSCT) or solid organ transplant (SOT) is a significant cause of morbidity and mortality in drug-refractory patients. Adoptive transfer of allogeneic virus-specific cytotoxic T… read more here.
Keywords: specific cytotoxic; using ifn; ifn gamma; virus specific ... See more keywords
Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy
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DOI: 10.1038/s41467-021-23442-z
Abstract: Radiotherapy (RT)-induced tumoricidal immunity is severely limited when tumors are well-established. Here, we report that depleting SIRPα on intratumoral macrophages augments efficacy of RT to eliminate otherwise large, treatment-resistant colorectal (MC38) and pancreatic (Pan02 and… read more here.
Keywords: specific cytotoxic; deficient macrophages; intratumoral sirp; sirp deficient ... See more keywords
Viral‐specific cytotoxic T‐cell responses in HLA‐sensitized kidney transplant patients maintained on everolimus and low‐dose tacrolimus
Sign Up to like & getrecommendations! Published in 2022 at "Transplant Infectious Disease"
DOI: 10.1111/tid.13805
Abstract: Maintenance with “everolimus + reduced dose tacrolimus” (Ev + Taclow) was reported to reduce the risk of viral infections compared to “tacrolimus + mycophenolate mofetil” (Tac + MMF). Here we examined viremia and viral‐specific T‐cell… read more here.
Keywords: dose tacrolimus; hla sensitized; specific cytotoxic; viral specific ... See more keywords
EBV‐specific cytotoxic T lymphocytes for refractory EBV‐associated post‐transplant lymphoproliferative disorder in solid organ transplant recipients: a systematic review
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DOI: 10.1111/tri.14107
Abstract: The use of Epstein–Barr virus‐specific cytotoxic T lymphocytes (EBV‐CTLs) in adoptive immunotherapy in hematopoietic stem cell transplantation (HSCT) patients with post‐transplantation lymphoproliferative disorder (PTLD) has demonstrated safety and effectiveness. EBV‐CTLs might also be the effective… read more here.
Keywords: ptld; ebv ctls; specific cytotoxic; lymphoproliferative disorder ... See more keywords
Interrupting the nitrosative stress fuels tumor-specific cytotoxic T lymphocytes in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003549
Abstract: Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest tumors owing to its robust desmoplasia, low immunogenicity, and recruitment of cancer-conditioned, immunoregulatory myeloid cells. These features strongly limit the success of immunotherapy as a… read more here.
Keywords: tumor; cancer; specific cytotoxic; myeloid cells ... See more keywords
Selection of Tumor-Specific Cytotoxic T Lymphocytes in Acute Myeloid Leukemia Patients Through the Identification of T-Cells Capable to Establish Stable Interactions With the Leukemic Cells: “Doublet Technology”
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01971
Abstract: The relevance of the immune system in cancer has long been studied. Autologous adoptive T cell therapies, based on the use of tumor infiltrating lymphocytes (TILs), have made great progress in recent years for the… read more here.
Keywords: specific cytotoxic; myeloid leukemia; acute myeloid; cell ... See more keywords