Delayed maturation of thymic epithelium in mice with specific deletion of β-catenin gene in FoxN1 positive cells.
Sign Up to like & getrecommendations! Published in 2021 at "Histochemistry and cell biology"
DOI: 10.1007/s00418-021-02012-w
Abstract: Wnt signalling pathways have been reported to be involved in thymus development but their precise role in the development of both thymic epithelium (TE) and thymocytes is controversial. Herein, we examined embryonic, postnatal and adult… read more here.
Keywords: mice specific; deletion catenin; specific deletion; maturation ... See more keywords
A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.09.008
Abstract: Multiple sclerosis (MS) is a human neurodegenerative disease characterized by the invasion of autoreactive T cells from the periphery into the CNS. Application of pan-histone deacetylase inhibitors (HDACi) ameliorates experimental autoimmune encephalomyelitis (EAE), an animal… read more here.
Keywords: specific deletion; autoimmune encephalomyelitis; hdac1; cell ... See more keywords
Dendritic cell-specific deletion of PKCδ in offspring of allergic mothers prevents the predisposition for development of allergic lung inflammation in offspring.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiae207
Abstract: In humans and in mice, maternal allergy predisposes offspring to development of allergy. In murine models, increased levels of maternal β-glucosylceramides are both necessary and sufficient for the development of allergic predisposition in offspring. Furthermore,… read more here.
Keywords: cell specific; specific deletion; dendritic cell; cell ... See more keywords
Oligodendrocyte‐specific deletion of FGFR2 ameliorates MOG35‐55‐induced EAE through ERK and Akt signalling
Sign Up to like & getrecommendations! Published in 2020 at "Brain Pathology"
DOI: 10.1111/bpa.12916
Abstract: Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in demyelinating pathologies including multiple sclerosis (MS). In our recent study, oligodendrocyte‐specific deletion of FGFR1 resulted in a milder disease course, less inflammation, reduced myelin… read more here.
Keywords: oligodendrocyte specific; specific deletion; eae; fgfr2 ... See more keywords
Myeloid‐specific deletion of activating transcription factor 6 alpha increases CD11b+ macrophage subpopulations and aggravates lung fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12637
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung disease of unknown etiology. The accumulation of macrophages is associated with disease pathogenesis. The unfolded protein response (UPR) has been linked to macrophage activation… read more here.
Keywords: specific deletion; fibrosis; myeloid specific; macrophage ... See more keywords
Abstract P216: Distal Convoluted Tubule-Specific Deletion of Specific Deletion of (Pro)Renin Receptor in Mice Increases Energy Expenditure and Enhances Aggressiveness
Sign Up to like & getrecommendations! Published in 2024 at "Hypertension"
DOI: 10.1161/hyp.81.suppl_1.p216
Abstract: Our previous study suggested a potential role of (pro)renin receptor (PRR) in the regulation of Na + -Cl - cotransporter (NCC) activity in the distal convoluted tubule (DCT). Here, we employed Slc12a3 -CreERT2 to generate… read more here.
Keywords: mice; specific deletion; group; energy expenditure ... See more keywords
β Cell–specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.154198
Abstract: Insulin secretion from pancreatic β cells is essential for glucose homeostasis. An insufficient response to the demand for insulin results in diabetes. We previously showed that β cell–specific deletion of Zfp148 (β-Zfp148KO) improves glucose tolerance… read more here.
Keywords: cell; zfp148ko islets; zfp148; specific deletion ... See more keywords
Neural stem cell-specific deletion of Atg7 alleviates hippocampal dysfunction and neuronal alterations induced by chronic restraint stress
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Brain"
DOI: 10.1186/s13041-025-01189-8
Abstract: Adult hippocampal neurogenesis is inhibited by chronic psychological stress and impaired neurogenesis underlies stress-related psychological disorders. We previously reported that chronic restraint stress (CRS) evokes autophagic death of adult hippocampal neural stem cells (NSCs) while… read more here.
Keywords: stress; chronic restraint; specific deletion; deletion atg7 ... See more keywords
Hematopoietic-Specific Deletion of Foxo1 Promotes NK Cell Specification and Proliferation
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01016
Abstract: We previously reported that deletion of Foxo1, via Ncr1-iCre mice from the expression of NKp46 onward, led to enhanced natural killer (NK) cell maturation and effector function. In this model, however, the role of Foxo1… read more here.
Keywords: hematopoietic specific; foxo1; specific deletion; deletion foxo1 ... See more keywords
Piezo1 specific deletion in macrophage protects the progression of liver fibrosis in mice: Erratum
Sign Up to like & getrecommendations! Published in 2025 at "Theranostics"
DOI: 10.7150/thno.107640
Abstract: [This corrects the article DOI: 10.7150/thno.86103.]. read more here.
Keywords: protects progression; macrophage protects; deletion macrophage; progression liver ... See more keywords