Delayed maturation of thymic epithelium in mice with specific deletion of β-catenin gene in FoxN1 positive cells.
Sign Up to like & getrecommendations! Published in 2021 at "Histochemistry and cell biology"
DOI: 10.1007/s00418-021-02012-w
Abstract: Wnt signalling pathways have been reported to be involved in thymus development but their precise role in the development of both thymic epithelium (TE) and thymocytes is controversial. Herein, we examined embryonic, postnatal and adult… read more here.
Keywords: mice specific; deletion catenin; specific deletion; maturation ... See more keywords
A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.09.008
Abstract: Multiple sclerosis (MS) is a human neurodegenerative disease characterized by the invasion of autoreactive T cells from the periphery into the CNS. Application of pan-histone deacetylase inhibitors (HDACi) ameliorates experimental autoimmune encephalomyelitis (EAE), an animal… read more here.
Keywords: specific deletion; autoimmune encephalomyelitis; hdac1; cell ... See more keywords
Oligodendrocyte‐specific deletion of FGFR2 ameliorates MOG35‐55‐induced EAE through ERK and Akt signalling
Sign Up to like & getrecommendations! Published in 2020 at "Brain Pathology"
DOI: 10.1111/bpa.12916
Abstract: Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in demyelinating pathologies including multiple sclerosis (MS). In our recent study, oligodendrocyte‐specific deletion of FGFR1 resulted in a milder disease course, less inflammation, reduced myelin… read more here.
Keywords: oligodendrocyte specific; specific deletion; eae; fgfr2 ... See more keywords
Myeloid‐specific deletion of activating transcription factor 6 alpha increases CD11b+ macrophage subpopulations and aggravates lung fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12637
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung disease of unknown etiology. The accumulation of macrophages is associated with disease pathogenesis. The unfolded protein response (UPR) has been linked to macrophage activation… read more here.
Keywords: specific deletion; fibrosis; myeloid specific; macrophage ... See more keywords
β Cell–specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.154198
Abstract: Insulin secretion from pancreatic β cells is essential for glucose homeostasis. An insufficient response to the demand for insulin results in diabetes. We previously showed that β cell–specific deletion of Zfp148 (β-Zfp148KO) improves glucose tolerance… read more here.
Keywords: cell; zfp148ko islets; zfp148; specific deletion ... See more keywords
Hematopoietic-Specific Deletion of Foxo1 Promotes NK Cell Specification and Proliferation
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01016
Abstract: We previously reported that deletion of Foxo1, via Ncr1-iCre mice from the expression of NKp46 onward, led to enhanced natural killer (NK) cell maturation and effector function. In this model, however, the role of Foxo1… read more here.
Keywords: hematopoietic specific; foxo1; specific deletion; deletion foxo1 ... See more keywords