Extracellular Vesicle Nanoarchitectonics for Novel Drug Delivery Applications.
Sign Up to like & getrecommendations! Published in 2021 at "Small"
DOI: 10.1002/smll.202102220
Abstract: Extracellular vesicles (EVs) can transfer intercellular messages in various (patho)physiological processes and transport biomolecules to recipient cells. EVs possess the capacity to evade the immune system and remain stable over long periods, identifying them as… read more here.
Keywords: extracellular vesicle; specific delivery; vesicle nanoarchitectonics; drug delivery ... See more keywords
Brain-Targeted HFn-Cu-REGO Nanoplatform for Site-Specific Delivery and Manipulation of Autophagy and Cuproptosis in Glioblastoma.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202205354
Abstract: Durable glioblastoma multiforme (GBM) management requires long-term chemotherapy after surgery to eliminate remaining cancerous tissues. Among chemotherapeutics, temozolomide is considered as the first-line drug for GBM therapy, but the treatment outcome is not satisfactory. Notably,… read more here.
Keywords: specific delivery; autophagy cuproptosis; gbm; site specific ... See more keywords
Tissue-Specific Delivery of Oligonucleotides.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9670-4_2
Abstract: From the initial discovery of short-interfering RNA (siRNA) and antisense oligonucleotides for specific gene knockdown at the posttranscriptional level to the current CRISPR-Cas9 system offering gene editing at the genomic level, oligonucleotides, in addition to… read more here.
Keywords: tissue specific; specific delivery; delivery; delivery oligonucleotides ... See more keywords
The programmed site-specific delivery of LY3200882 and PD-L1 siRNA boosts immunotherapy for triple-negative breast cancer by remodeling tumor microenvironment.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2022.121518
Abstract: Despite the remarkable success of immunotherapies over the past decade, their effectiveness against triple-negative breast cancer (TNBC) is limited to a small subset of patients, mainly due to the low immunogenicity and unfavorable tumor microenvironment.… read more here.
Keywords: programmed site; microenvironment; specific delivery; site specific ... See more keywords
Famotidine microspheres reconstituted with floating in situ gel for stomach-specific delivery: Preparation and characterization
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2017.07.017
Abstract: Abstract Considering the benefits of stomach-specific delivery of H 2 -antagonists, the objective of the present investigation was to develop and characterize a floating in situ gel containing famotidine–chitosan (FM-CS) microspheres. FM-CS microspheres were prepared… read more here.
Keywords: stomach specific; delivery; specific delivery; situ gel ... See more keywords
A Multifunctional Lipid-based Nanodevice for the Highly-specific Co-delivery of Sorafenib and Midkine siRNA to Hepatic Cancer Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00738
Abstract: Hepatocellular carcinoma (HCC), a common deadly malignancy, requires novel therapeutic strategies to improve the survival rate. Combining chemotherapy and gene therapy is a promising approach for increasing efficiency and reducing side effects. We report on… read more here.
Keywords: specific delivery; highly specific; delivery; hepatic cancer ... See more keywords
Nano-formulations for bone-specific delivery of siRNA for CrkII silencing-induced regulation of bone formation and resorption to maximize therapeutic potential for bone-related diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm02038f
Abstract: CrkII, a member of the adaptor protein family, is known to participate in bone homeostasis via the regulation of osteoclasts and osteoblasts. Therefore, silencing CrkII would beneficially impact the bone microenvironment. In this study, CrkII… read more here.
Keywords: specific delivery; bone specific; bone; liposome sicrkii ... See more keywords
Colon specific delivery of miR-155 inhibitor alleviates estrogen deficiency related phenotype via microbiota remodeling
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2108163
Abstract: Abstract Compelling data have indicated menopause-associated increase in cardiovascular disease in women, while the underlying mechanisms remain largely unknown. It is established that changes of intestinal microbiota affect cardiovascular function in the context of metabolic… read more here.
Keywords: specific delivery; mir 155; function; microbiota ... See more keywords
Abstract LB169: Systemic Administration of an antibody/RNA complex results in tumor specific delivery of immunostimulatory RNAs and tumor growth suppression in a mouse model of melanoma
Sign Up to like & getrecommendations! Published in 2021 at "Immunology"
DOI: 10.1158/1538-7445.am2021-lb169
Abstract: There is intense interest in the development of nucleic acid ligands for immune stimulation of the tumor microenvironment via pattern recognition receptors, especially for the treatment of “cold” tumors. However, delivery of these ligands in… read more here.
Keywords: tumor specific; specific delivery; tumor growth; tumor ... See more keywords