Population-specific design of de-immunized protein biotherapeutics
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005983
Abstract: Immunogenicity is a major problem during the development of biotherapeutics since it can lead to rapid clearance of the drug and adverse reactions. The challenge for biotherapeutic design is therefore to identify mutants of the… read more here.
Keywords: protein; immunogenicity; specific design; population specific ... See more keywords
Mining Domain-Specific Design Patterns: A Case Study
Sign Up to like & getrecommendations! Published in 2017 at "Algorithms"
DOI: 10.3390/a10010028
Abstract: Domain-specific design patterns provide developers with proven solutions to common design problems that arise, particularly in a target application domain, facilitating them to produce quality designs in the domain contexts. However, research in this area… read more here.
Keywords: methodology; specific design; domain specific; design patterns ... See more keywords