MENIN loss as a tissue-specific driver of tumorigenesis
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.09.032
Abstract: The MEN1 gene encodes MENIN, a tumor suppressor that plays a role in multiple cellular processes. Germline and somatic mutations in MEN1 have been identified in hereditary and sporadic tumors of neuroendocrine origins suggesting context-specific… read more here.
Keywords: tissue specific; menin loss; specific driver; driver tumorigenesis ... See more keywords
An evolution-based machine learning to identify cancer type-specific driver mutations
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac593
Abstract: Identifying cancer type-specific driver mutations is crucial for illuminating distinct pathologic mechanisms across various tumors and providing opportunities of patient-specific treatment. However, although many computational methods were developed to predict driver mutations in a type-specific… read more here.
Keywords: cancer; specific driver; type specific; cancer type ... See more keywords
Inferring subgroup-specific driver genes from heterogeneous cancer samples via subspace learning with subgroup indication
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz793
Abstract: MOTIVATION Detecting driver genes from gene mutation data is a fundamental task for tumorigenesis research. Due to the fact that cancer is a heterogeneous disease with various subgroups, subgroup specific driver genes are the key… read more here.
Keywords: driver; driver genes; subgroup specific; specific driver ... See more keywords