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MENIN loss as a tissue-specific driver of tumorigenesis

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0 Published in 2018 at "Molecular and Cellular Endocrinology"

DOI: 10.1016/j.mce.2017.09.032

Abstract: The MEN1 gene encodes MENIN, a tumor suppressor that plays a role in multiple cellular processes. Germline and somatic mutations in MEN1 have been identified in hereditary and sporadic tumors of neuroendocrine origins suggesting context-specific… read more here.

Keywords: tissue specific; menin loss; specific driver; driver tumorigenesis ... See more keywords

Privacy-Preserving Identification of Cancer Subtype-Specific Driver Genes Based on Multigenomics Data with Privatedriver

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0 Published in 2024 at "Journal of Computational Biology"

DOI: 10.1089/cmb.2023.0115

Abstract: Identifying cancer subtype-specific driver genes from a large number of irrelevant passengers is crucial for targeted therapy in cancer treatment. Recently, the rapid accumulation of large-scale cancer genomics data from multiple institutions has presented remarkable… read more here.

Keywords: cancer; driver; driver genes; specific driver ... See more keywords

An evolution-based machine learning to identify cancer type-specific driver mutations

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1 Published in 2022 at "Briefings in bioinformatics"

DOI: 10.1093/bib/bbac593

Abstract: Identifying cancer type-specific driver mutations is crucial for illuminating distinct pathologic mechanisms across various tumors and providing opportunities of patient-specific treatment. However, although many computational methods were developed to predict driver mutations in a type-specific… read more here.

Keywords: cancer; specific driver; type specific; cancer type ... See more keywords

Inferring subgroup-specific driver genes from heterogeneous cancer samples via subspace learning with subgroup indication

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0 Published in 2020 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btz793

Abstract: MOTIVATION Detecting driver genes from gene mutation data is a fundamental task for tumorigenesis research. Due to the fact that cancer is a heterogeneous disease with various subgroups, subgroup specific driver genes are the key… read more here.

Keywords: driver; driver genes; subgroup specific; specific driver ... See more keywords

Identification of clinicopathological‐specific driver gene and genetic subtyping of colorectal cancer

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0 Published in 2025 at "Cancer Science"

DOI: 10.1111/cas.16432

Abstract: This study analyzed targeted sequencing data from 6530 tissue samples from patients with metastatic Chinese colorectal cancer (CRC) to identify low mutation frequency and subgroup‐specific driver genes, using three algorithms for overall CRC as well… read more here.

Keywords: cancer; driver; crc; driver gene ... See more keywords