Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations
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DOI: 10.7554/elife.58997
Abstract: LRRK2 is a kinase expressed in striatal spiny projection neurons (SPNs), cells which lose dopaminergic input in Parkinson’s disease (PD). R1441C and G2019S are the most common pathogenic mutations of LRRK2. How these mutations alter… read more here.
Keywords: excitatory; specific dysregulation; pathway specific; lrrk2 mutations ... See more keywords