Chimeric Zika viruses containing structural protein genes of insect-specific flaviviruses cannot replicate in vertebrate cells due to entry and post-translational restrictions.
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DOI: 10.1016/j.virol.2021.03.014
Abstract: Long Pine Key virus (LPKV) and Lammi virus are insect-specific flaviviruses that phylogenetically affiliate with dual-host flaviviruses. The goal of this study was to provide insight into the genetic determinants that condition this host range… read more here.
Keywords: vertebrate cells; insect specific; specific flaviviruses; entry ... See more keywords
Chimeric Vaccines Based on Novel Insect-Specific Flaviviruses
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DOI: 10.3390/vaccines9111230
Abstract: Vector-borne flaviviruses are responsible for nearly half a billion human infections worldwide each year, resulting in millions of cases of debilitating and severe diseases and approximately 115,000 deaths. While approved vaccines are available for some… read more here.
Keywords: insect specific; specific flaviviruses; flavivirus diseases; based novel ... See more keywords