Co-culture system of hepatocytes and endothelial cells: two in vitro approaches for enhancing liver-specific functions of hepatocytes
Sign Up to like & getrecommendations! Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0219-3
Abstract: Although hepatocyte transplantation and bioartificial liver support system provide new promising opportunities for those patients waiting for liver transplantation, hepatocytes are easily losing liver-specific functions by using the common in vitro cultured methods. The co-culture… read more here.
Keywords: system; specific functions; liver specific; culture ... See more keywords
The role of ERα36 in cell type-specific functions of estrogen and cancer development.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105307
Abstract: Exploring the regulatory effects of estrogen on different body organs via its receptors is largely of interest. Recently, the expression, signaling and the clinical significance of ERα36, the newly identified isoform of ERα, mediating non-genomic… read more here.
Keywords: type specific; specific functions; role; functions estrogen ... See more keywords
Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14666
Abstract: The guidance protein Semaphorin7A (Sema7A) is required for the proper development of the immune and nervous systems. Despite strong expression in the mature brain, the role of Sema7A in the adult remains poorly defined. Here… read more here.
Keywords: adult; specific functions; hippocampal neurogenesis; stage specific ... See more keywords
Lineage-specific functions of TET1 in the postimplantation mouse embryo
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3868
Abstract: The mammalian TET enzymes catalyze DNA demethylation. While they have been intensely studied as major epigenetic regulators, little is known about their physiological roles and the extent of functional redundancy following embryo implantation. Here we… read more here.
Keywords: specific functions; mouse embryo; functions tet1; lineage specific ... See more keywords
An expectation–maximization framework for comprehensive prediction of isoform-specific functions
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad132
Abstract: Abstract Motivation Advances in RNA sequencing technologies have achieved an unprecedented accuracy in the quantification of mRNA isoforms, but our knowledge of isoform-specific functions has lagged behind. There is a need to understand the functional… read more here.
Keywords: isoform; isoform specific; ontology; specific functions ... See more keywords
Common and Specific Functions of Nonmuscle Myosin II Paralogs in Cells
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297918120040
Abstract: Various forms of cell motility critically depend on pushing, pulling, and resistance forces generated by the actin cytoskeleton. Whereas pushing forces largely depend on actin polymerization, pulling forces responsible for cell contractility and resistance forces… read more here.
Keywords: specific functions; paralogs cells; functions nonmuscle; myosin paralogs ... See more keywords
Prolyl Isomerization-Mediated Conformational Changes Define ATR Subcellular Compartment-Specific Functions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.826576
Abstract: ATR is a PI3K-like kinase protein, regulating checkpoint responses to DNA damage and replication stress. Apart from its checkpoint function in the nucleus, ATR actively engages in an antiapoptotic role at mitochondria following DNA damage.… read more here.
Keywords: trans atr; compartment specific; isomerization; atr ... See more keywords
The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.563166
Abstract: Cardiovascular diseases are one of the prime reasons for disability and death worldwide. Diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia, might initiate cardiac remodeling and dysfunction by inducing hypertrophy or apoptosis… read more here.
Keywords: type specific; specific functions; functions mir; cardiovascular diseases ... See more keywords
Cytosolic Hsp90 Isoform-Specific Functions and Clinical Significance
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12091166
Abstract: The heat shock protein 90 (Hsp90) is a molecular chaperone and a key regulator of proteostasis under both physiological and stress conditions. In mammals, there are two cytosolic Hsp90 isoforms: Hsp90α and Hsp90β. These two… read more here.
Keywords: cytosolic hsp90; isoform; specific functions; hsp90 isoform ... See more keywords
Insights into Cell-Specific Functions of Microtubules in Skeletal Muscle Development and Homeostasis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032903
Abstract: The contractile cells of skeletal muscles, called myofibers, are elongated multinucleated syncytia formed and maintained by the fusion of proliferative myoblasts. Human myofibers can be hundreds of microns in diameter and millimeters in length. Myofibers… read more here.
Keywords: development; muscle; insights cell; specific functions ... See more keywords