C/EBPß Isoform Specific Gene Regulation: It’s a Lot more Complicated than you Think!
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Mammary Gland Biology and Neoplasia"
DOI: 10.1007/s10911-020-09444-5
Abstract: It has been almost 30 years since C/EBPß was discovered. Seminal studies have shown that C/EBPß is a master regulator of mammary gland development and has been shown to control and influence proliferation and differentiation through… read more here.
Keywords: ebp isoform; isoform; isoform specific; breast cancer ... See more keywords
A unique histone 3 lysine 14 chromatin signature underlies tissue-specific gene regulation.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.01.041
Abstract: Organismal development and cell differentiation critically depend on chromatin state transitions. However, certain developmentally regulated genes lack histone 3 lysine 9 and 27 acetylation (H3K9ac and H3K27ac, respectively) and histone 3 lysine 4 (H3K4) methylation,… read more here.
Keywords: tissue specific; histone lysine; lysine; specific gene ... See more keywords
Pathogen Recognition-Driven Dendritic Cell-Specific Gene Silencing and Editing.
Sign Up to like & getrecommendations! Published in 2023 at "Nano letters"
DOI: 10.1021/acs.nanolett.3c00015
Abstract: Dendritic cells (DCs) play an essential role in both the induction of the immune response and the maintenance of immune tolerance, with any malfunction of DCs potentially causing several diseases. While gene-based therapy for DC… read more here.
Keywords: recognition; gene silencing; specific gene; gene ... See more keywords
Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04295-5
Abstract: The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene… read more here.
Keywords: gene families; gene expression; specific gene; malaria parasites ... See more keywords
Adaptive NetworkProfiler for Identifying Cancer Characteristic-Specific Gene Regulatory Networks.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Computational Biology"
DOI: 10.1089/cmb.2017.0120
Abstract: Abstract There is currently much discussion about sample (patient)-specific gene regulatory network identification, since the efficiently constructed sample-specific gene networks lead to effective personalized cancer therapy. Although statistical approaches have been proposed for inferring gene… read more here.
Keywords: networkprofiler; gene regulatory; specific gene; cancer ... See more keywords
Evolution of a new form of haploid-specific gene regulation appearing in a limited clade of ascomycete yeast species.
Sign Up to like & getrecommendations! Published in 2023 at "Genetics"
DOI: 10.1093/genetics/iyad053
Abstract: Over evolutionary timescales, the logic and pattern of cell-type specific gene expression can remain constant, yet the molecular mechanisms underlying such regulation can drift between alternative forms. Here, we document a new example of this… read more here.
Keywords: haploid specific; specific gene; regulation; gene ... See more keywords
Simultaneous inference of phenotype-associated genes and relevant tissues from GWAS data via Bayesian integration of multiple tissue-specific gene networks
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjx059
Abstract: Although genome-wide association studies (GWAS) have successfully identified thousands of genomic loci associated with hundreds of complex traits in the past decade, the debate about such problems as missing heritability and weak interpretability has been… read more here.
Keywords: tissue specific; gene networks; specific gene; gwas data ... See more keywords
A Stage-Specific Gene Expression Framework for Promoting Genetic Algorithm
Sign Up to like & getrecommendations! Published in 2023 at "IEEE Access"
DOI: 10.1109/access.2023.3272356
Abstract: Genetic algorithm (GA) has become very popular for tackling computationally expensive numerical optimization problems. To optimize their performance and convergence rate, we propose and demonstrate an embedded stage-specific gene expression framework (SGEF) with a two-tier… read more here.
Keywords: expression framework; stage specific; genetic algorithm; algorithm ... See more keywords
Acute wheeze-specific gene module shows correlation with vitamin D and asthma medication
Sign Up to like & getrecommendations! Published in 2019 at "European Respiratory Journal"
DOI: 10.1183/13993003.01330-2019
Abstract: Background Airway obstruction and wheezing in preschool children with recurrent viral infections are a major clinical problem, and are recognised as a risk factor for the development of chronic asthma. We aimed to analyse whether… read more here.
Keywords: acute wheeze; specific gene; wheeze specific; medication ... See more keywords
HMEJ-mediated efficient site-specific gene integration in chicken cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biological Engineering"
DOI: 10.1186/s13036-019-0217-9
Abstract: BackgroundThe production of transgenic chicken cells holds great promise for several diverse areas, including developmental biology and biomedical research. To this end, site-specific gene integration has been an attractive strategy for generating transgenic chicken cell… read more here.
Keywords: integration; site specific; specific gene; chicken cells ... See more keywords
A novel feature extraction method based on highly expressed SNPs for tissue-specific gene prediction
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Big Data"
DOI: 10.1186/s40537-021-00497-9
Abstract: Background Gene expression provides a means for an organism to produce gene products necessary for the organism to live. Variation in the significant gene expression levels can distinguish the gene and the tissue in which… read more here.
Keywords: tissue specific; feature; tissue; specific gene ... See more keywords