Evaluation of Lou et al.: Proposed benefits of a population-specific genome reference.
Sign Up to like & getrecommendations! Published in 2022 at "Cell systems"
DOI: 10.1016/j.cels.2022.03.005
Abstract: One snapshot of the peer review process for "Haplo-type-resolved de novo assembly of a Tujia genome suggests the necessity for high-quality population-specific genome references" (Lou et al., 2022). read more here.
Keywords: population specific; evaluation lou; proposed benefits; lou proposed ... See more keywords
Multiplexed site-specific genome engineering for overproducing bioactive secondary metabolites in actinomycetes.
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2017.01.004
Abstract: Actinomycetes produce a large variety of pharmaceutically active compounds, yet production titers often require to be improved for discovery, development and large-scale manufacturing. Here, we describe a new technique, multiplexed site-specific genome engineering (MSGE) via… read more here.
Keywords: multiplexed site; engineering; specific genome; site specific ... See more keywords
High-throughput genetic engineering of nonmodel and undomesticated bacteria via iterative site-specific genome integration
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade1285
Abstract: Efficient genome engineering is critical to understand and use microbial functions. Despite recent development of tools such as CRISPR-Cas gene editing, efficient integration of exogenous DNA with well-characterized functions remains limited to model bacteria. Here,… read more here.
Keywords: integration; specific genome; high throughput; site specific ... See more keywords