Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell Hyperproliferation
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DOI: 10.1016/j.stemcr.2017.09.012
Abstract: Summary Mammalian oocytes possess fascinating unknown factors, which can reprogram terminally differentiated germ cells or somatic cells into totipotent embryos. Here, we demonstrate that oocyte-specific homeobox 1 (Obox1), an oocyte-specific factor, can markedly enhance the… read more here.
Keywords: hyperproliferation; oocyte specific; specific homeobox; cell ... See more keywords
PO-318 Intestine-specific homeobox gene ISX integrates IL6 signaling, tryptophan catabolism, and immune suppression
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DOI: 10.1136/esmoopen-2018-eacr25.831
Abstract: Introduction The intestine-specific homeobox transcription factor intestine specific homeobox (ISX) is an IL6-inducible protooncogene implicated in the development of hepatocellular carcinoma, but its mechanistic contributions to this process are undefined. Material and methods In this… read more here.
Keywords: hepatocellular carcinoma; intestine specific; immune suppression; tryptophan ... See more keywords
Abstract 1108: Intestine-specific homeobox recruits p300/CBP-associated factor and bromodomain-containing protein 4 to promote epithelial-mesenchymal transition
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DOI: 10.1158/1538-7445.am2019-1108
Abstract: The epithelial-mesenchymal transition is an important process in the cancer progression, but its occurrence and the regulatory mechanism are not fully understood. Intestine specific homeobox acted both as a proto-oncogene and upstream regulator of EMT… read more here.
Keywords: bromodomain containing; containing protein; epithelial mesenchymal; specific homeobox ... See more keywords