Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer’s disease mice and correlates with memory deficits in human subjects
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DOI: 10.1038/s41598-018-31073-6
Abstract: Calpain hyperactivation is implicated in late-stages of neurodegenerative diseases including Alzheimer’s disease (AD). However, calpains are also critical for synaptic function and plasticity, and hence memory formation and learning. Since synaptic deficits appear early in… read more here.
Keywords: calpain; specific hyperactivation; alzheimer disease; hyperactivation ... See more keywords