Specific Inhibition of Viral MicroRNAs by Carbon Dots-Mediated Delivery of Locked Nucleic Acids for Therapy of Virus-Induced Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "ACS nano"
DOI: 10.1021/acsnano.9b06333
Abstract: Viruses are associated with up to 15% of human cancer. MicroRNAs (miRNAs) encoded by numerous oncogenic viruses including Kaposi's sarcoma-associated herpesvirus (KSHV) play significant roles in regulating the proliferation and survival of virus-induced cancer cells,… read more here.
Keywords: specific inhibition; induced cancer; inhibition viral; carbon dots ... See more keywords
Specific inhibition of splicing factor activity by decoy RNA oligonucleotides
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09523-0
Abstract: Alternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this process, are up- or down regulated or mutated in several diseases including cancer. To date, there… read more here.
Keywords: specific inhibition; inhibition splicing; splicing factor; decoy oligonucleotides ... See more keywords
Alcohol-Specific Inhibition Training in Patients with Alcohol Use Disorder: A Multicenter, Double-Blind, Randomized Clinical Trial Examining Drinking Outcome and Working Mechanisms.
Sign Up to like & getrecommendations! Published in 2022 at "Addiction"
DOI: 10.1111/add.16104
Abstract: AIMS For the first time in a clinical sample with alcohol use disorder (AUD), this study compared the effects of two versions of alcohol-specific inhibition training (Alc-IT) on drinking outcomes and on experimental parameters assessing… read more here.
Keywords: specific inhibition; alcohol specific; inhibition; inhibition training ... See more keywords
BCL6 BTB‐specific inhibition via FX1 treatment reduces Tfh cells and reverses lymphoid follicle hyperplasia in Indian rhesus macaque (Macaca mulatta)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Primatology"
DOI: 10.1111/jmp.12438
Abstract: The BTB domain of B‐cell lymphoma 6 (BCL6) protein was identified as a therapeutic target for B‐cell lymphoma. This study compared the pharmacokinetics (PK) of the BCL6 BTB inhibitor (FX1) between mice and macaques, as… read more here.
Keywords: btb; specific inhibition; bcl6 btb; btb specific ... See more keywords