Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.03.010
Abstract: α-Synuclein (α-syn) overload is strongly associated with Parkinson disease (PD), and reduction of the α-syn level by targeting the peptide-based system through the autophagy-lysosomal pathway (ALP) is a promising strategy to delay PD progression. However,… read more here.
Keywords: degradation; syn; knockdown synuclein; proteasome degradation ... See more keywords
Neuron‐specific knockdown of Drosophila HADHB induces a shortened lifespan, deficient locomotive ability, abnormal motor neuron terminal morphology and learning disability
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2019.03.040
Abstract: &NA; Mutations in the HADHB gene induce dysfunctions in the beta‐oxidation of fatty acids and result in a MTP deficiency, which is characterized by clinical heterogeneity, such as cardiomyopathy and recurrent Leigh‐like encephalopathy. In contrast,… read more here.
Keywords: drosophila; specific knockdown; hadhb; neuron specific ... See more keywords
Regular Exercise in Drosophila Prevents Age-Related Cardiac Dysfunction Caused by High Fat and Heart-Specific Knockdown of skd
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021216
Abstract: Skuld (skd) is a subunit of the Mediator complex subunit complex. In the heart, skd controls systemic obesity, is involved in systemic energy metabolism, and is closely linked to cardiac function and aging. However, it… read more here.
Keywords: specific knockdown; cardiac function; drosophila; heart ... See more keywords