Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101202
Abstract: Objective Impaired circadian clocks can cause obesity, but their pathophysiological role in brown adipose tissue (BAT), a major tissue regulating energy metabolism, remains unclear. To address this issue, we investigated the effects of complete disruption… read more here.
Keywords: bmal1; brown adipocyte; bat; adipocyte specific ... See more keywords
ENDOTHELIAL-SPECIFIC KNOCKOUT OF THE SCRAMBLASE TMEM16F IMPAIRS IN VIVO CLOT FORMATION
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DOI: 10.1097/shk.0000000000002553
Abstract: ABSTRACT Objective: Loss of function of the phospholipid scramblase (PLS) TMEM16F results in Scott syndrome, a hereditary bleeding disorder generally attributed to intrinsic platelet dysfunction. The role of TMEM16F in endothelial cells, however, is not… read more here.
Keywords: endothelial specific; time; bleeding; tmem16f ... See more keywords
Podocyte specific knockout of the natriuretic peptide clearance receptor is podocyte protective in focal segmental glomerulosclerosis
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DOI: 10.1371/journal.pone.0319424
Abstract: Natriuretic peptides (NPs) bind to glomerular podocytes and attenuate glomerular injury. The beneficial effects of NPs are negatively regulated by the NP clearance receptor (NPRC), which is highly expressed in podocytes. To determine if inhibiting… read more here.
Keywords: podocyte specific; podocyte protective; podocyte; specific knockout ... See more keywords
Cardiac Fibroblast-Specific Knockout of PGC-1α Accelerates AngII-Induced Cardiac Remodeling
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DOI: 10.3389/fcvm.2021.664626
Abstract: Cardiac remodeling consisted of ventricular hypertrophy and interstitial fibrosis is the pathological process of many heart diseases. Fibroblasts as one of the major cells in the myocardium regulate the balance of the generation and degeneration… read more here.
Keywords: induced cardiac; cardiac fibroblast; cardiac remodeling; fibroblast specific ... See more keywords
Sex-Dependent Effects of HO-1 Deletion from Adipocytes in Mice
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DOI: 10.3390/ijms18030611
Abstract: Induction of heme oxygenase-1 (HO-1) has been demonstrated to decrease body weight and improve insulin sensitivity in several models of obesity in rodents. To further study the role of HO-1 in adipose tissue, we created… read more here.
Keywords: fat diet; sex dependent; specific knockout; body ... See more keywords