PO-209 Biological characterisation of specific KRAS mutations: from basic biology to response to treatment
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DOI: 10.1136/esmoopen-2018-eacr25.244
Abstract: Introduction KRAS is one of the most frequently mutated oncogenes in cancer and KRAS mutations are commonly associated with resistance to therapy and poor prognosis. KRAS is still not directly druggable, therefore current therapeutic strategies… read more here.
Keywords: response; vitro vivo; specific kras; biology ... See more keywords
Isoform-Specific KRAS-Hexokinase 1 Interaction Affects Metabolism.
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DOI: 10.1158/2159-8290.cd-rw2019-189
Abstract: KRAS4A, but not KRAS4B, directly interacts with hexokinase 1 (HK1) on outer mitochondrial membranes. read more here.
Keywords: affects metabolism; kras hexokinase; specific kras; hexokinase interaction ... See more keywords