Attenuated Codon Optimality Contributes to Neural-Specific mRNA Decay in Drosophila
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.07.039
Abstract: SUMMARY Tissue-specific mRNA stability is important for cell fate and physiology, but the mechanisms involved are not fully understood. We found that zygotic mRNA stability in Drosophila correlates with codon content: optimal codons are enriched… read more here.
Keywords: optimal codons; nervous system; specific mrna; codon optimality ... See more keywords
Helper-Polymer Based Five-Element Nanoparticles (FNPs) for Lung-Specific mRNA Delivery with Long-Term Stability after Lyophilization.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c01784
Abstract: Lipid nanoparticles (LNPs) carrying therapeutic mRNAs hold great promise in treating lung-associated diseases like viral infections, tumors, and genetic disorders. However, because of their thermodynamically unstable nature, traditional LNPs carrying mRNAs need to be stored… read more here.
Keywords: specific mrna; mrna delivery; lung specific; lung ... See more keywords
SARS-CoV-2 Variant-Specific mRNA Vaccine: Pros and Cons.
Sign Up to like & getrecommendations! Published in 2023 at "Viral immunology"
DOI: 10.1089/vim.2022.0121
Abstract: Emerging severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants have raised concerns about the efficacy of vaccines. The present study aimed to compare the potential of Delta and Omicron variant-specific mRNA vaccines in inducing immune responses.… read more here.
Keywords: delta; specific mrna; variant specific; mrna vaccine ... See more keywords
Changes in Expression of Specific mRNA Transcripts after Single- or Re-Irradiation in Mouse Testes
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13010151
Abstract: Alkylating agents and irradiation induce testicular damage, which results in prolonged azoospermia. Even very low doses of radiation can significantly impair testis function. However, re-irradiation is an effective strategy for locally targeted treatments and the… read more here.
Keywords: specific mrna; irradiation; mrna transcripts; cell ... See more keywords