33 LANDSCAPE OF ALLELE-SPECIFIC OPEN CHROMATIN IN HUMAN IPSC-DIFFERENTIATED NEURONS AND IT IMPLICATION FOR MENTAL DISORDERS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.034
Abstract: Background Allelic Imbalance of gene Expression (AIE) plays important role during neurodevelopment. However, the underlying mechanism of AIE has not been fully understood. Since chromatin accessibility (openness) has a strong influence on gene transcription, we… read more here.
Keywords: chromatin; open chromatin; specific open; allele specific ... See more keywords
Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.aay3983
Abstract: Effects of allele-specific open chromatin Genetic variants in noncoding regions of the genome may underlie the development of disease. However, we are just beginning to tease apart the function of such variants associated with neuropsychiatric… read more here.
Keywords: chromatin; disease; open chromatin; specific open ... See more keywords