Construction of Discrete Model of Human Pluripotency in Predicting Lineage-Specific Outcomes and Targeted Knockdowns of Essential Genes
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DOI: 10.1038/s41598-018-29480-w
Abstract: A network consisting of 45 core genes was developed for the genes/proteins responsible for loss/gain of function in human pluripotent stem cells. The nodes were included on the basis of literature curation. The initial network… read more here.
Keywords: topology; model; lineage specific; human pluripotency ... See more keywords
Smoking, alcohol consumption and disease-specific outcomes in rheumatic and musculoskeletal diseases (RMDs): systematic reviews informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs
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DOI: 10.1136/rmdopen-2021-002170
Abstract: Background A EULAR taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). The aim of this paper was to review the literature on the relationship between smoking and alcohol… read more here.
Keywords: alcohol consumption; systematic reviews; smoking alcohol; specific outcomes ... See more keywords
S152 Investigating the role of fluoroquinolones in the treatment of isoniazid resistant tuberculosis: implications for the 2018 WHO guidance
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DOI: 10.1136/thorax-2018-212555.158
Abstract: 2018 World Health Organization (WHO) guidelines for isoniazid resistant (INH-R) tuberculosis recommend a treatment regimen of four drugs continuously for six months- rifampicin, pyrazinamide, ethambutol, and levofloxacin; with or without isoniazid ([H]RZE-Lfx)- once drug sensitivity… read more here.
Keywords: fluoroquinolones treatment; regimen specific; treatment; isoniazid resistant ... See more keywords