Ubiquitin-specific peptidase 39 regulates the process of proliferation and migration of human ovarian cancer via p53/p21 pathway and EMT
Sign Up to like & getrecommendations! Published in 2019 at "Medical Oncology"
DOI: 10.1007/s12032-019-1308-7
Abstract: Ovarian cancer is one of the most lethal gynecological cancers; owning to its late detection and chemoresistance, understanding the pathogenesis of this malignant tumor is much critical. Previous studies have reported that ubiquitin-specific peptidase 39… read more here.
Keywords: ubiquitin specific; migration; ovarian cancer; human ovarian ... See more keywords
Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43180
Abstract: The overexpression of Mdm2 has been linked to the loss of p53 tumour suppressor activity in several human cancers. Here, we present results suggesting that ubiquitin-specific peptidase 48 (USP48), a deubiquitinase that has been linked… read more here.
Keywords: deubiquitinase; specific peptidase; deubiquitinase activity; mdm2 ... See more keywords
USP1 (ubiquitin specific peptidase 1) targets ULK1 and regulates its cellular compartmentalization and autophagy
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2018.1535291
Abstract: ABSTRACT ULK1 (unc-51 like autophagy activating kinase 1) is a core component at multiple steps of canonical macroautophagy/autophagy. The activity of ULK1 is tightly regulated by several post-translational modifications, including ubiquitination, yet the deubiquitinase (DUB)… read more here.
Keywords: ubiquitin specific; complementation group; usp1 ubiquitin; autophagy ... See more keywords
Ubiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-κB pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2033403
Abstract: ABSTRACT Clear cell renal cell carcinoma, the most common type of renal cancer, is associated with poor survival. Ubiquitin-specific peptidase 2 regulates the molecular mechanisms of cancer cells. However, its mechanism in clear cell renal… read more here.
Keywords: cell renal; cell; specific peptidase; ubiquitin specific ... See more keywords
Ubiquitin-specific peptidase 30-mediated deubiquitination of forkhead box O3 promotes the progression of subarachnoid hemorrhage by regulating cGAS/STING pathway
Sign Up to like & getrecommendations! Published in 2025 at "Neuroreport"
DOI: 10.1097/wnr.0000000000002192
Abstract: Background Subarachnoid hemorrhage (SAH) is a cerebrovascular disease with a very high disability and mortality rate, which brings a huge economic burden to society. It is reported that inhibition of forkhead box O3 (FOXO3) can… read more here.
Keywords: specific peptidase; deubiquitination; pyroptosis; forkhead box ... See more keywords
Ubiquitin-specific peptidase 24 accelerates aerobic glycolysis and tumor progression in gastric carcinoma through stabilizing PLK1 to activate NOTCH1.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer science"
DOI: 10.1111/cas.15847
Abstract: Ubiquitin-specific peptidase 24 (USP24), a member of the deubiquitinase family, plays an important role in tumor regulation. However, the role of USP24 in gastric cancer (GC) is unknown. The aim of our study was to… read more here.
Keywords: tumor progression; specific peptidase; ubiquitin specific; glycolysis ... See more keywords
Abstract 335: Ubiquitin Specific Peptidase 37promotes Osteosarcoma oncogenesis by interacting with PCNA and impacting constitutive replication fork movement.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-335
Abstract: Osteosarcoma is the heterogeneous primary malignancy of bone which is most commonly found among children and adolescents. Recent data related to treatment of osteosarcoma indicates the lack information about the progression of the disease. Osteosarcoma… read more here.
Keywords: replication fork; osteosarcoma; replication; specific peptidase ... See more keywords
Abstract Or110: Inflammation-induced endothelial cell activation and angiogenic sprouting are downmodulated by ubiquitin-specific peptidase 20
Sign Up to like & getrecommendations! Published in 2024 at "Circulation Research"
DOI: 10.1161/res.135.suppl_1.or110
Abstract: The deubiquitinase ubiquitin-specific peptidase 20 (USP20) reverses lysine-63 ubiquitination of the signaling adaptor TRAF6 and suppresses nuclear-factor-κB (NFκB) activation induced by proatherogenic stimuli in vascular smooth muscle cells (SMCs). Dephosphorylation of USP20 at Ser 334… read more here.
Keywords: specific peptidase; cell activation; activation; angiogenesis ... See more keywords
Targeted analysis of Ubiquitin-Specific Peptidase (USP8) in a population of Iranian people with Cushing’s disease and a systematic review of the literature
Sign Up to like & getrecommendations! Published in 2024 at "BMC Endocrine Disorders"
DOI: 10.1186/s12902-024-01619-z
Abstract: Activating mutation in Ubiquitin-specific peptidase (USP8) is identified to enhance cell proliferation and adrenocorticotropic hormone (ACTH) secretion from corticotroph pituitary adenoma. We investigated the USP8 variant status in a population of Iranian people with functional… read more here.
Keywords: specific peptidase; review; systematic review; population iranian ... See more keywords
Ubiquitin specific peptidase 49 inhibits renal fibrosis through protein phosphatase magnesium-dependent1A-mediated Smad2/3 pathway
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Medical Science"
DOI: 10.5114/aoms/132228
Abstract: 23 Introduction: Renal fibrosis is one of the common pathologies of chronic kidney disease. 24 This study aimed to investigate the function of ubiquitin specific peptidase 49 (USP49) in 25 renal fibrosis and to explore… read more here.
Keywords: expression; specific peptidase; fibrosis; ubiquitin specific ... See more keywords
Ubiquitin specific peptidase 8 is critical for the onset of infectious osteomyelitis by targeting RIPK2 ubiquitination.
Sign Up to like & getrecommendations! Published in 2023 at "Japanese journal of infectious diseases"
DOI: 10.7883/yoken.jjid.2022.515
Abstract: Receptor interacting serine/threonine kinase (RIPK) 2 is associated with cellular inflammation and immune regulation. The current study explored the roles of RIPK2 in osteomyelitis and the potential upstream targets of RIPK2. S. aureus-induced osteomyelitis mouse… read more here.
Keywords: osteomyelitis; specific peptidase; ubiquitin specific; ripk2 ubiquitination ... See more keywords