CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-27227-2
Abstract: Animals are essential genetic tools in scientific research and global resources in agriculture. In both arenas, a single sex is often required in surplus. The ethical and financial burden of producing and culling animals of… read more here.
Keywords: cas9 effectors; specific phenotypes; crispr cas9; sex ... See more keywords
Community composition shapes microbial-specific phenotypes in a cystic fibrosis polymicrobial model system
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DOI: 10.1101/2022.06.23.497319
Abstract: Interspecies interactions can drive the emergence of unexpected microbial phenotypes that are not observed when studying monocultures. The cystic fibrosis (CF) lung consists of a complex environment where particular microbes, living as polymicrobial biofilm-like communities,… read more here.
Keywords: specific phenotypes; community; model; community specific ... See more keywords
Medications for specific phenotypes of heart failure with preserved ejection fraction classified by a machine learning-based clustering model
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DOI: 10.1136/heartjnl-2022-322181
Abstract: Objective Our previously established machine learning-based clustering model classified heart failure with preserved ejection fraction (HFpEF) into four distinct phenotypes. Given the heterogeneous pathophysiology of HFpEF, specific medications may have favourable effects in specific phenotypes… read more here.
Keywords: heart failure; specific phenotypes; machine learning; based clustering ... See more keywords