Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111919
Abstract: Phosphatidylcholine-specific phospholipase C (PC-PLC) is a promising target for new anticancer treatment. Herein, we report our work in the discovery of novel drug-like PC-PLC inhibitors. Virtual screening led to the identification of promising hits from… read more here.
Keywords: phosphatidylcholine specific; drug; specific phospholipase; discovery novel ... See more keywords
Phosphatidylinositol-specific phospholipase C enhances epidermal penetration by Staphylococcus aureus
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DOI: 10.1038/s41598-020-74692-8
Abstract: Staphylococcus aureus (S. aureus) commonly colonizes the human skin and nostrils. However, it is also associated with a wide variety of diseases. S. aureus is frequently isolated from the skin of patients with atopic dermatitis… read more here.
Keywords: staphylococcus aureus; aureus; skin; phosphatidylinositol specific ... See more keywords
Characterization of the Glehnia littoralis Non-specific Phospholipase C Gene GlNPC3 and Its Involvement in the Salt Stress Response
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.769599
Abstract: Glehnia littoralis is a medicinal halophyte that inhabits sandy beaches and has high ecological and commercial value. However, the molecular mechanism of salt adaptation in G. littoralis remains largely unknown. Here, we cloned and identified… read more here.
Keywords: specific phospholipase; glnpc3; non specific; gene ... See more keywords