Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15428-0
Abstract: There are thousands of known cellular phosphorylation sites, but the paucity of ways to identify kinases for particular phosphorylation events remains a major roadblock for understanding kinase signaling. To address this, we here develop a… read more here.
Keywords: kinase; inhibition; phosphorylation sites; specific phosphorylation ... See more keywords
PKSPS: a novel method for predicting kinase of specific phosphorylation sites based on maximum weighted bipartite matching algorithm and phosphorylation sequence enrichment analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab436
Abstract: With the development of biotechnology, a large number of phosphorylation sites have been experimentally confirmed and collected, but only a few of them have kinase annotations. Since experimental methods to detect kinases at specific phosphorylation… read more here.
Keywords: kinase; phosphorylation sites; specific phosphorylation; pksps ... See more keywords
Phosformer: an explainable transformer model for protein kinase-specific phosphorylation predictions
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad046
Abstract: Abstract Motivation The human genome encodes over 500 distinct protein kinases which regulate nearly all cellular processes by the specific phosphorylation of protein substrates. While advances in mass spectrometry and proteomics studies have identified thousands… read more here.
Keywords: kinase specific; kinase; specific phosphorylation; model ... See more keywords