The Next Step Forward in Ubiquitin-Specific Protease 7 Selective Inhibition.
Sign Up to like & getrecommendations! Published in 2017 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2017.12.003
Abstract: Ubiquitin-specific protease 7 is a validated anticancer target; thus, selective USP7 inhibitors are of great interest. In this issue of Cell Chemical Biology, Lamberto et al. (2017) and Pozhidaeva et al. (2017) report important insights into the… read more here.
Keywords: step forward; next step; specific protease; ubiquitin specific ... See more keywords
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01933
Abstract: USP21 belongs to the ubiquitin-specific protease (USP) subfamily of deubiquitinating enzymes (DUBs). Due to its relevance in tumor development and growth, USP21 has been reported as a promising novel therapeutic target for cancer treatment. Herein,… read more here.
Keywords: bay 805; specific protease; inhibitor; ubiquitin specific ... See more keywords
The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28103-8
Abstract: Smad4, a common-mediator of Smads, plays a central role in forming complexes with receptor-phosphorylated Smads, and then transduces transforming growth factor (TGF)-β signals into the nuclei. Although many cellular factors are involved in TGF-β induced… read more here.
Keywords: sentrin specific; cell migration; specific protease; tgf ... See more keywords
Identification of ubiquitin-specific protease 32 as an oncogene in glioblastoma and the underlying mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-09497-y
Abstract: Glioblastoma (GBM) patients present poor prognosis. Deubiquitination by deubiquitinating enzymes (DUBs) is a critical process in cancer progression. Ubiquitin-specific proteases (USPs) constitute the largest sub-family of DUBs. Evaluate the role of USP32 in GBM progression… read more here.
Keywords: glioblastoma; protease oncogene; specific protease; oncogene glioblastoma ... See more keywords
A patent review of ubiquitin-specific protease 7 (USP7) inhibitors (2014-present)
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2022.2058873
Abstract: ABSTRACT Introduction Ubiquitin-specific protease 7 (USP7) plays a critical role in multiple signaling pathways, and many recent studies have proved its association with many diseases. The USP7-murine double minute 2-p53 pathway and the relationship between… read more here.
Keywords: specific protease; ubiquitin specific; protease usp7; usp7 inhibitors ... See more keywords
SUMO-specific protease 1 inhibitors–A literature and patent overview
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2022.2165910
Abstract: ABSTRACT Introduction Cancer is currently one of the biggest killers threatening human health. More and more studies have confirmed that SUMO-specific protease 1 (SENP1) is over-expressed in various cancer tissues. Therefore, targeting SENP1 expression may… read more here.
Keywords: specific protease; sumo specific; inhibitors literature; protease inhibitors ... See more keywords
The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad140
Abstract: Abstract The RNA exosome is an essential 3′ to 5′ exoribonuclease complex that mediates degradation, processing and quality control of virtually all eukaryotic RNAs. The nucleolar RNA exosome, consisting of a nine-subunit core and a… read more here.
Keywords: specific protease; protease usp36; ubiquitin specific; rna exosome ... See more keywords
Ubiquitin‐specific protease 28 deubiquitinates TCF7L2 to govern the action of the Wnt signaling pathway in hepatic carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15509
Abstract: Overexpression of ubiquitin‐specific protease 28 (USP28) is found in hepatic carcinoma. It is unclear whether the deubiquitinase plays a role in hepatocarcinogenesis. Deregulation of the Wnt signaling pathway is frequently associated with liver cancer. Transcription… read more here.
Keywords: specific protease; signaling pathway; ubiquitin specific; wnt signaling ... See more keywords
Functional loss of ubiquitin‐specific protease 14 may lead to a novel distal arthrogryposis phenotype
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Genetics"
DOI: 10.1111/cge.14117
Abstract: Multiple congenital contractures (MCC) comprise a number of rare, non‐progressive conditions displaying marked phenotypic and etiologic heterogeneity. A genetic cause can be established in approximately half of the affected individuals, attributed to genetic defects in… read more here.
Keywords: ubiquitin specific; distal arthrogryposis; specific protease; phenotype ... See more keywords
Pharmacological inhibition of USP7 suppresses growth and metastasis of melanoma cells in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16834
Abstract: Melanoma is a highly aggressive type of skin cancer. The development of diverse resistance mechanisms and severe adverse effects significantly limit the efficiency of current therapeutic approaches. Identification of the new therapeutic targets involved in… read more here.
Keywords: melanoma; specific protease; ubiquitin specific; inhibition ... See more keywords
Proinflammatory Effects of Ubiquitin-Specific Protease 5 (USP5) in Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Sign Up to like & getrecommendations! Published in 2020 at "Mediators of Inflammation"
DOI: 10.1155/2020/8295149
Abstract: Rheumatoid arthritis (RA) is a worldwide chronic autoimmune inflammatory disease which is affecting approximately 1% of the total population. It is characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS) and increased production of proinflammatory cytokines.… read more here.
Keywords: fibroblast like; like synoviocytes; protease usp5; specific protease ... See more keywords