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   Articles with "specific protease" as a keyword



Transcriptional regulation of basophil‐specific protease genes by C/EBPα, GATA2, TGF‐β signaling, and epigenetic mechanisms

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recommendations! Published in 2024 at "Febs Letters"

DOI: 10.1002/1873-3468.15069

Abstract: Basophils and mast cells (MCs) play an important role in immune responses against allergens and parasitic infection. To elucidate the mechanisms that determine the commitment between basophils and mast cell (MCs), transcription factors and epigenetic… read more here.

Keywords: protease genes; gata2 tgf; mcpt8 prss34; basophil specific ... See more keywords

Blocking Ubiquitin‐Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl‐CoA Desaturase

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202307899

Abstract: Gastric cancer (GC) presents a formidable global health challenge, and conventional therapies face efficacy limitations. Ubiquitin‐specific protease 7 (USP7) plays pivotal roles in GC development, immune response, and chemo‐resistance, making it a promising target. Various… read more here.

Keywords: coa desaturase; gastric cancer; ubiquitin specific; stearoyl coa ... See more keywords
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The Next Step Forward in Ubiquitin-Specific Protease 7 Selective Inhibition.

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recommendations! Published in 2017 at "Cell chemical biology"

DOI: 10.1016/j.chembiol.2017.12.003

Abstract: Ubiquitin-specific protease 7 is a validated anticancer target; thus, selective USP7 inhibitors are of great interest. In this issue of Cell Chemical Biology, Lamberto et al. (2017) and Pozhidaeva et al. (2017) report important insights into the… read more here.

Keywords: step forward; next step; specific protease; ubiquitin specific ... See more keywords

Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21

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recommendations! Published in 2023 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.2c01933

Abstract: USP21 belongs to the ubiquitin-specific protease (USP) subfamily of deubiquitinating enzymes (DUBs). Due to its relevance in tumor development and growth, USP21 has been reported as a promising novel therapeutic target for cancer treatment. Herein,… read more here.

Keywords: bay 805; specific protease; inhibitor; ubiquitin specific ... See more keywords

Ubiquitin-Specific Protease 7 (USP7) as a Promising Therapeutic Target for Drug Discovery: From Mechanisms to Therapies.

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recommendations! Published in 2025 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.5c00102

Abstract: Protein ubiquitination is a reversible post-translational modification regulated by ubiquitin-conjugating and deubiquitinating enzymes (DUBs). Ubiquitin-specific protease 7 (USP7), a well-characterized DUB, plays multifaceted roles in various cellular processes, making it a promising therapeutic target. The… read more here.

Keywords: protease usp7; drug discovery; ubiquitin specific; therapeutic target ... See more keywords

Targeting Ubiquitin-Specific Protease 7 (USP7): A Pharmacophore-Guided Drug Repurposing and Physics-Based Molecular Simulation Study

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recommendations! Published in 2025 at "ACS Omega"

DOI: 10.1021/acsomega.5c03150

Abstract: Ubiquitin-Specific Protease 7 (USP7) has emerged as a critical therapeutic target in cancer due to its regulatory roles of tumor suppressors, oncoproteins, and epigenetic modifiers. In this study, we present a comprehensive drug repurposing strategy… read more here.

Keywords: drug repurposing; protease usp7; physics; ubiquitin specific ... See more keywords

The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-28103-8

Abstract: Smad4, a common-mediator of Smads, plays a central role in forming complexes with receptor-phosphorylated Smads, and then transduces transforming growth factor (TGF)-β signals into the nuclei. Although many cellular factors are involved in TGF-β induced… read more here.

Keywords: sentrin specific; cell migration; specific protease; tgf ... See more keywords
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Identification of ubiquitin-specific protease 32 as an oncogene in glioblastoma and the underlying mechanisms

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recommendations! Published in 2022 at "Scientific Reports"

DOI: 10.1038/s41598-022-09497-y

Abstract: Glioblastoma (GBM) patients present poor prognosis. Deubiquitination by deubiquitinating enzymes (DUBs) is a critical process in cancer progression. Ubiquitin-specific proteases (USPs) constitute the largest sub-family of DUBs. Evaluate the role of USP32 in GBM progression… read more here.

Keywords: glioblastoma; protease oncogene; specific protease; oncogene glioblastoma ... See more keywords

Ubiquitin-specific protease UBP14 stabilizes HY5 by deubiquitination to promote photomorphogenesis in Arabidopsis thaliana

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2404883121

Abstract: Significance For the initial growth of seedlings, the transcription factor ELONGATED HYPOCOTYL5 (HY5) plays a critical role by initiating a series of light responses. Here, we demonstrated that besides transcription activity of HY5, the HY5… read more here.

Keywords: protease ubp14; hy5; ubiquitin specific; photomorphogenesis ... See more keywords

Activation dynamics of ubiquitin-specific protease 7

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2426632122

Abstract: Significance Ubiquitin-specific protease 7 (USP7), a deubiquitinating enzyme linked to cancers and neurodevelopmental disorders, adopts an inactive ground conformation and requires substrate binding for activation. Using NMR and enzyme kinetic analyses, we unravel the enzyme… read more here.

Keywords: dynamics ubiquitin; activation dynamics; activation; ubiquitin specific ... See more keywords

A patent review of ubiquitin-specific protease 7 (USP7) inhibitors (2014-present)

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recommendations! Published in 2022 at "Expert Opinion on Therapeutic Patents"

DOI: 10.1080/13543776.2022.2058873

Abstract: ABSTRACT Introduction Ubiquitin-specific protease 7 (USP7) plays a critical role in multiple signaling pathways, and many recent studies have proved its association with many diseases. The USP7-murine double minute 2-p53 pathway and the relationship between… read more here.

Keywords: specific protease; ubiquitin specific; protease usp7; usp7 inhibitors ... See more keywords