Effective inhibition of C3a-mediated pro-inflammatory response by a human C3a-specific protein binder.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.27309
Abstract: Complement component 3a (C3a) plays a crucial role in the immune response and host defense, but it is also involved in pro-inflammatory responses, causing many inflammatory disorders. Blockade of C3a has been regarded as a… read more here.
Keywords: c3a; protein binder; response; specific protein ... See more keywords
Sensitive amperometric immunosensor with improved electrocatalytic Au@Pd urchin-shaped nanostructures for human epididymis specific protein 4 antigen detection.
Sign Up to like & getrecommendations! Published in 2019 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2019.04.023
Abstract: Sensitive detection of early ovarian cancer is imminent for women's health. Human epididymis specific protein 4 antigen (HE4 Ag), as a novel tumor marker, has good specificity and sensitivity in ovarian cancer markers, especially for… read more here.
Keywords: protein antigen; immunosensor; epididymis specific; human epididymis ... See more keywords
Growth arrest specific protein 7 inhibits tau fibrillogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.03.041
Abstract: Here we show that Gas7 inhibits phosphorylated tau fibrillogenesis by binding to phosphorylated tau at its non-WW domain, presumably F-BAR domain. We revealed that Gas7 binds to the third repeat domain of tau, the core… read more here.
Keywords: arrest specific; fibrillogenesis; growth arrest; specific protein ... See more keywords
Highly Specific Protein Identification by Immunoprecipitation–Mass Spectrometry Using Antifouling Microbeads
Sign Up to like & getrecommendations! Published in 2022 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.1c22734
Abstract: A common method to study protein complexes is immunoprecipitation (IP), followed by mass spectrometry (thus labeled: IP-MS). IP-MS has been shown to be a powerful tool to identify protein–protein interactions. It is, however, often challenging… read more here.
Keywords: specific protein; highly specific; mass spectrometry; protein ... See more keywords
Site-Specific Protein Labeling and Generation of Defined Ubiquitin-Protein Conjugates Using an Asparaginyl Endopeptidase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c02191
Abstract: Asparaginyl endopeptidases (AEPs) have recently been widely utilized for peptide and protein modification. Labeling is however restricted to protein termini, severely limiting flexibility and scope in creating diverse conjugates as needed for therapeutic and diagnostic… read more here.
Keywords: specific protein; protein labeling; generation; site specific ... See more keywords
Site-Specific Protein Labeling with N-Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b05098
Abstract: N-Hydroxysuccinimide (NHS)-esters are widely used to label proteins nonselectively on free amino groups. Such broad labeling can be disadvantageous because it can interfere with protein structure or function and because stoichiometry is poorly controlled. Here… read more here.
Keywords: protein; site specific; protein labeling; ubiquitin ligase ... See more keywords
Specific protein labeling with caged fluorophores for dual-color imaging and super-resolution microscopy in living cells† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc02088g Click here for additional data file.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Science"
DOI: 10.1039/c6sc02088g
Abstract: We present new fluorophore-conjugates for dual-color photoactivation and super-resolution imaging inside live mammalian cells. read more here.
Keywords: specific protein; dual color; super resolution; microscopy ... See more keywords
ChromLoops: a comprehensive database for specific protein-mediated chromatin loops in diverse organisms
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac893
Abstract: Abstract Chromatin loops (or chromatin interactions) are important elements of chromatin structures. Disruption of chromatin loops is associated with many diseases, such as cancer and polydactyly. A few methods, including ChIA-PET, HiChIP and PLAC-Seq, have… read more here.
Keywords: specific protein; protein mediated; mediated chromatin; chromatin loops ... See more keywords
Antitumor activity of antibody against cytotoxic T lymphocyte epitope peptide of lymphocyte‐specific protein tyrosine kinase
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Science"
DOI: 10.1111/cas.13522
Abstract: Although humoral responses against CTL epitope peptides from lymphocyte‐specific protein tyrosine kinase (Lck) antigen have been observed in the majority of healthy donors and cancer patients, the biological activity of the antibody has not been… read more here.
Keywords: specific protein; protein tyrosine; epitope; activity ... See more keywords
Fat‐specific protein 27α inhibits autophagy‐dependent lipid droplet breakdown in white adipocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13050
Abstract: Fat‐specific protein 27 (FSP27) α is the major isoform of FSP27 in white adipose tissue (WAT), and is essential for large unilocular lipid droplet (LD) formation in white adipocytes. In contrast, FSP27β is abundantly expressed… read more here.
Keywords: white adipocytes; fat specific; specific protein; lipid droplet ... See more keywords
Elevated Levels of Urinary Extracellular Vesicle Fibroblast-Specific Protein 1 in Patients with Active Crescentic Glomerulonephritis
Sign Up to like & getrecommendations! Published in 2018 at "Nephron"
DOI: 10.1159/000495217
Abstract: Background/Aims: Extracellular vesicles (EVs), including exosomes, are present in various bodily fluids, including urine. We and others previously reported that cells expressing fibroblast-specific protein 1 (FSP1) accumulate within damaged glomeruli, and that urinary FSP1, as… read more here.
Keywords: fibroblast specific; specific protein; soluble cd163; levels urinary ... See more keywords