Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-14269-w
Abstract: Speciation is associated with substantial rewiring of the regulatory circuitry underlying the expression of genes. Determining which changes are relevant and underlie the emergence of the human brain or its unique susceptibility to neural disease… read more here.
Keywords: autism patients; autism; hominin specific; elements selectively ... See more keywords
Subtype-specific regulatory network rewiring in acute myeloid leukemia
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DOI: 10.1038/s41588-018-0270-1
Abstract: Acute myeloid leukemia (AML) is a heterogeneous disease caused by a variety of alterations in transcription factors, epigenetic regulators and signaling molecules. To determine how different mutant regulators establish AML subtype–specific transcriptional networks, we performed… read more here.
Keywords: network; subtype specific; myeloid leukemia; acute myeloid ... See more keywords
Retinoic Acid-Containing Liposomes for the Induction of Antigen-Specific Regulatory T Cells as a Treatment for Autoimmune Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13111949
Abstract: The current treatment of autoimmune and chronic inflammatory diseases entails systemic immune suppression, which is associated with increased susceptibility to infections. To restore immune tolerance and reduce systemic side effects, a targeted approach using tolerogenic… read more here.
Keywords: treatment autoimmune; antigen specific; antigen; retinoic acid ... See more keywords