Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis‐Specific Serine/Threonine Kinase 2 (TSSK2)
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DOI: 10.1002/cmdc.201700503
Abstract: Testis‐specific serine/threonine kinase 2 (TSSK2) is an important target for reversible male contraception. A high‐throughput screen of ≈17 000 compounds using a mobility shift assay identified two potent series of inhibitors having a pyrrolopyrimidine or pyrimidine core.… read more here.
Keywords: specific serine; serine threonine; kinase; pyrimidine ... See more keywords
TPCA-1 compound, inhibiting testis-specific serine/threonine protein kinase 3 for potential male sterile in Bombyx mori.
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DOI: 10.1002/ps.8347
Abstract: BACKGROUND Protein kinases are a type of transferase enzyme that catalyze the phosphorylation of protein substrates, including receptor proteins. Testis-specific serine/threonine kinases (TSSKs) are a highly conserved group of protein kinases found in various organisms.… read more here.
Keywords: bombyx mori; serine threonine; testis specific; protein ... See more keywords
Loss-of-function in testis-specific serine/threonine protein kinase triggers male infertility in an invasive moth
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DOI: 10.1038/s42003-024-06961-5
Abstract: Genetic biocontrol technologies present promising and eco-friendly strategies for the management of pest and insect-transmitted diseases. Although considerable advancements achieve in gene drive applications targeting mosquitoes, endeavors to combat agricultural pests have been somewhat restricted.… read more here.
Keywords: threonine protein; serine threonine; threonine; protein kinase ... See more keywords