Disease and subtype specific signatures enable precise diagnosis of the mucopolysaccharidoses
Sign Up to like & getrecommendations! Published in 2018 at "Genetics in Medicine"
DOI: 10.1038/s41436-018-0136-z
Abstract: PurposeExpanding treatments for the mucopolysaccharidoses—a family of genetic disorders—place unprecedented demands for accurate, timely diagnosis because best outcomes are seen with early initiation of appropriate therapies. Here we sought to improve the diagnostic odyssey by… read more here.
Keywords: diagnosis; disease subtype; subtype specific; glycosaminoglycan fragments ... See more keywords
Phenotype‐specific signatures of systems‐level gut microbiome associated with childhood airway allergies
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DOI: 10.1111/pai.13905
Abstract: Perturbation of gut symbiosis has been linked to childhood allergic diseases. However, the underlying host–microbe interaction connected with specific phenotypes is poorly understood. read more here.
Keywords: level gut; phenotype specific; signatures systems; childhood ... See more keywords
Glucose metabolism controls disease-specific signatures of macrophage effector functions.
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DOI: 10.1172/jci.insight.123047
Abstract: BACKGROUND In inflammatory blood vessel diseases, macrophages represent a key component of the vascular infiltrates and are responsible for tissue injury and wall remodeling. METHODS To examine whether inflammatory macrophages in the vessel wall display… read more here.
Keywords: disease specific; controls disease; glucose metabolism; metabolism controls ... See more keywords