A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Genome research"
DOI: 10.1101/gr.227181.117
Abstract: Pre-mRNA splicing can contribute to the switch of cell identity that occurs in carcinogenesis. Here, we analyze a large collection of RNA-seq data sets and report that splicing changes in hepatocyte-specific enzymes, such as AFMID… read more here.
Keywords: recurrence; afmid isoforms; switch; switch alternatively ... See more keywords
A site-specific switch for cancer cells.
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.356.6343.1134-i
Abstract: Cancer To metastasize, cancer cells must switch from epithelial (polarized and fixed) into mesenchymal (motile and invasive) phenotypes to disseminate and colonize both primary and metastatic sites. Zhou et al. found that the long noncoding… read more here.
Keywords: cancer; site specific; specific switch; cancer cells ... See more keywords