Linkage‐Specific Synthesis of Di‐ubiquitin Probes Enabled by the Incorporation of Unnatural Amino Acid ThzK
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DOI: 10.1002/cbic.202200133
Abstract: Di‐ubiquitin (diUB) conjugates of defined linkages are useful tools for probing the functions of UB ligases, UB‐binding proteins and deubiquitinating enzymes (DUBs) in coding, decoding and editing the signals carried by the UB chains. Here… read more here.
Keywords: incorporation unnatural; linkage; specific synthesis; unnatural amino ... See more keywords
Site-Specific Synthesis of Protein-Oligo Conjugates through Histidine-Maleimide-Mediated Imidazolidinone Formation.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00350
Abstract: Protein modifications are crucial for biological applications including detection and therapeutics. Methods that site-specifically modify target proteins are limited and demanding. Here, we present a novel N-terminal labeling technique that improves not only the conjugation… read more here.
Keywords: synthesis protein; protein oligo; specific synthesis; site specific ... See more keywords