Sequence‐specific targeting of chromatin remodelers organizes precisely positioned nucleosomes throughout the genome
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201600183
Abstract: Eukaryotic genomes are functionally organized into chromatin, a compact packaging of nucleoproteins with the basic repeating unit known as the nucleosome. A major focus for the chromatin field has been understanding what rules govern nucleosome… read more here.
Keywords: throughout genome; sequence specific; chromatin; positioned nucleosomes ... See more keywords
Myofibroblast specific targeting approaches to improve fibrosis treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc04825f
Abstract: Fibrosis has been shown to develop in individuals with underlying health conditions, especially chronic inflammatory diseases. Fibrosis is often diagnosed in various organs, including the liver, lungs, kidneys, heart, and skin, and has been described… read more here.
Keywords: collagen angiotensin; myofibroblast specific; specific targeting; treatment ... See more keywords
Translation rate underpins specific targeting of N-terminal transmembrane proteins to mitochondria.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13475
Abstract: Protein biogenesis is a complex process, and complexity is greatly increased in eukaryotic cells through specific targeting of proteins to different organelles. To direct targeting, organellar proteins carry an organelle-specific targeting signal for recognition by… read more here.
Keywords: rate underpins; translation rate; transmembrane; mitochondrial targeting ... See more keywords
113: SPECIFIC TARGETING OF HER2-POSITIVE BREAST CANCER CELL LINE (SK-BR3) USING IDARUBICIN-LOADED ANTI-HER2 IMMUNOLIPOSOME
Sign Up to like & getrecommendations! Published in 2017 at "BMJ Open"
DOI: 10.1136/bmjopen-2016-015415.113
Abstract: Cytotoxic chemotherapy drugs which are used for treating malignant cells cannot distinguish between normal and cancerous cells. This would lead to adverse side effects. Moreover, drug resistance is another major problem of the classical chemotherapy… read more here.
Keywords: cell; her2 positive; cell lines; breast cancer ... See more keywords
Specific Targeting of Notch Ligand-Receptor Interactions to Modulate Immune Responses: A Review of Clinical and Preclinical Findings
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01958
Abstract: Understanding and targeting Notch signaling effectively has long been valued in the field of cancer and other immune disorders. Here, we discuss key discoveries at the intersection of Notch signaling, cancer and immunology. While there… read more here.
Keywords: targeting notch; notch ligand; immune responses; ligand ... See more keywords
Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression: Erratum
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DOI: 10.7150/thno.48039
Abstract: [This corrects the article DOI: 10.7150/thno.37851.]. read more here.
Keywords: inhibits growth; pdgfr stroma; specific targeting; targeting pdgfr ... See more keywords
Tissue-specific targeting of DNA nanodevices in a multicellular living organism
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.67830
Abstract: Nucleic acid nanodevices present great potential as agents for logic-based therapeutic intervention as well as in basic biology. Often, however, the disease targets that need corrective action are localized in specific organs, and thus realizing… read more here.
Keywords: organism; tissue specific; dna; biology ... See more keywords