Overexpression of early T cell differentiation-specific transcription factors transforms the terminally differentiated effector T cells into less differentiated state.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2020.104118
Abstract: The in vivo proliferation and viability of transfused engineered T cells markedly limits the long-term effect of adoptive cell therapy on tumors. The therapeutic efficacy and proliferative potential of T cells are reported to be… read more here.
Keywords: cell; differentiation specific; specific transcription; differentiation ... See more keywords
Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate.
Sign Up to like & getrecommendations! Published in 2019 at "Cell stem cell"
DOI: 10.1016/j.stem.2019.02.006
Abstract: Hematopoiesis provides an accessible system for studying the principles underlying cell-fate decisions in stem cells. Proposed models of hematopoiesis suggest that quantitative changes in lineage-specific transcription factors (LS-TFs) underlie cell-fate decisions. However, evidence for such… read more here.
Keywords: quantitative changes; cell; specific transcription; cell fate ... See more keywords
Conjugated activation of myocardial-specific transcription of Gja5 by a pair of Nkx2-5-Shox2 co-responsive elements.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental biology"
DOI: 10.1016/j.ydbio.2020.07.003
Abstract: The sinoatrial node (SAN) is the primary pacemaker in the heart. During cardiogenesis, Shox2 and Nkx2-5 are co-expressed in the junction domain of the SAN and regulate pacemaker cell fate through a Shox2-Nkx2-5 antagonism. Cx40… read more here.
Keywords: nkx2 shox2; myocardial specific; specific transcription; gja5 ... See more keywords
Allele-specific transcription factor binding in a cellular model of orofacial clefting
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-05876-7
Abstract: Non-syndromic cleft lip with/without cleft palate (nsCL/P) is a frequent congenital malformation with multifactorial etiology. While recent genome-wide association studies (GWAS) have identified several nsCL/P risk loci, the functional effects of the associated non-coding variants… read more here.
Keywords: transcription factor; risk; specific transcription; allele specific ... See more keywords
Abstract 4334: Epigenetic reprogramming of tissue-specific transcription promotes metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-4334
Abstract: Metastasis is the cause of death for 90% of cancer patients, but little is known about how cancer cells adapt to and colonize new tissue environments. Colorectal cancer (CRC) is the third most common cancer… read more here.
Keywords: tissue specific; metastasis; cancer; transcription ... See more keywords
Suppression of the Testis-Specific Transcription of the ZBTB32 and ZNF473 Genes in Germ Cell Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Acta Naturae"
DOI: 10.32607/actanaturae.11620
Abstract: The family of genes containing C2H2 zinc finger domains, which has more than 700 members, is one of the largest in the genome. Of particular interest are C2H2 genes with potential tissue-specific transcription, which determine… read more here.
Keywords: germ cell; transcription; zbtb32 znf473; specific transcription ... See more keywords