CATCH: high specific transcriptome-focused fusion gene variants discrimination.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02660k
Abstract: We develop a CRISPR-Cas13a triggered catalytic hairpin assembly (CATCH) approach for accurate and impartial identification of variants by integrating the fusion gene-selected recognition of CRISPR-Cas13a with collateral cleavage-assisted catalytic hairpin assembly amplification. This approach achieved… read more here.
Keywords: fusion; catch high; high specific; specific transcriptome ... See more keywords
Qki5 safeguards spinal motor neuron function by defining the motor neuron-specific transcriptome via pre-mRNA processing
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2401531121
Abstract: Significance RNA-binding proteins (RBPs) play pivotal roles in a cellular RNA metabolism by regulating multiple steps of the posttranscriptional gene regulation and its functional abnormality is linked to pathogenesis of various diseases. Most of RBPs… read more here.
Keywords: neuron specific; motor; motor neuron; specific transcriptome ... See more keywords