Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-021-00924-7
Abstract: Phosphorylation of the pseudokinase mixed lineage kinase domain-like protein (MLKL) by the protein kinase RIPK3 targets MLKL to the cell membrane, where it triggers necroptotic cell death. We report that conjugation of K63-linked polyubiquitin chains… read more here.
Keywords: site specific; ubiquitination mlkl; cell death; mlkl ... See more keywords
Allosteric mechanism for site-specific ubiquitination of FANCD2
Sign Up to like & getrecommendations! Published in 2019 at "Nature chemical biology"
DOI: 10.1038/s41589-019-0426-z
Abstract: DNA-damage repair is implemented by proteins that are coordinated by specialized molecular signals. One such signal in the Fanconi anemia (FA) pathway for the repair of DNA interstrand crosslinks is the site-specific monoubiquitination of FANCD2… read more here.
Keywords: specific ubiquitination; mechanism; site specific; fancd2 ... See more keywords