Pivotal Evaluation of an Artificial Intelligence System for Autonomous Detection of Referrable and Vision-Threatening Diabetic Retinopathy.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2021.34254
Abstract: Importance Diabetic retinopathy (DR) is a leading cause of blindness in adults worldwide. Early detection and intervention can prevent blindness; however, many patients do not receive their recommended annual diabetic eye examinations, primarily owing to… read more here.
Keywords: detection; diabetic retinopathy; system; sensitivity ... See more keywords
Sensitivity and Specificity of the Modified Checklist for Autism in Toddlers (Original and Revised): A Systematic Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2022.5975
Abstract: Importance The Modified Checklist for Autism in Toddlers (M-CHAT) and the M-CHAT, Revised With Follow-up (M-CHAT-R/F)-henceforth referred to as M-CHAT(-R/F)-are the most commonly used toddler screeners for autism spectrum disorder (ASD). Their use often differs… read more here.
Keywords: autism; sensitivity specificity; meta analysis; specificity ... See more keywords
IRE1α nucleotide sequence cleavage specificity in the unfolded protein response
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12546
Abstract: Inositol‐requiring enzyme 1 (IRE1) is a conserved sensor of the unfolded protein response that has protein kinase and endoribonuclease (RNase) enzymatic activities and thereby initiates HAC1/XBP1 splicing. Previous studies demonstrated that human IRE1α (hIRE1α) does… read more here.
Keywords: cleavage; unfolded protein; protein response; cleavage specificity ... See more keywords
Specificity models in MAPK cascade signalling.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13619
Abstract: The precise execution of various cellular functions relies on the maintenance of signalling specificity from input detection to cellular outputs. However, diverse signalling pathways share similar or identical intermediate components. A well-conserved intermediate, the Mitogen-Activated… read more here.
Keywords: specificity models; mapk cascade; models mapk; specificity ... See more keywords
Switching the Cofactor Specificity of an Imine Reductase
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DOI: 10.1002/cctc.201701194
Abstract: In the last years, imine reductases (IREDs) have gained importance for the formation of chiral amines by catalyzing asymmetric reductions of imines and chemo‐ and stereoselective reductive aminations. However, all characterized members of this steadily… read more here.
Keywords: imine reductase; cofactor specificity; switching cofactor; specificity imine ... See more keywords
Molecular allergy diagnosis is sensitive and avoids misdiagnosis in patients sensitized to seasonal allergens
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Translational Allergy"
DOI: 10.1002/clt2.12231
Abstract: Abstract Background The specificity of extract‐based pollen allergy diagnosis is decreased due to cross‐reactivity via cross‐reactive carbohydrate determinants (CCDs) or panallergens such as profilins or polcalcins. This study aimed to explore the prevalence of sensitization… read more here.
Keywords: misdiagnosis; allergy diagnosis; diagnosis; pollen ... See more keywords
Leaf volatile and nonvolatile metabolites show different levels of specificity in response to herbivory
Sign Up to like & getrecommendations! Published in 2023 at "Ecology and Evolution"
DOI: 10.1002/ece3.10123
Abstract: Abstract Plants produce diverse chemical defenses with contrasting effects on different insect herbivores. Deploying herbivore‐specific responses can help plants increase their defensive efficiency. Here, we explore how variation in induced plant responses correlates with herbivore… read more here.
Keywords: volatile nonvolatile; nonvolatile leaf; leaf; specificity ... See more keywords
Does combining an informant questionnaire with patient performance scales improve diagnostic test accuracy for cognitive impairment?
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.4647
Abstract: Cognitive screening instruments (CSIs) may be broadly divided into those testing patient performance and those questioning an informant for collateral history (Larner, 2017). The Alzheimer Association has recommended the combined use of an informant interview… read more here.
Keywords: cognitive impairment; series; performance; test ... See more keywords
Age‐specificity and generalization of behavior‐associated structural and functional networks and their relevance to behavioral domains
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.25759
Abstract: Behavior‐associated structural connectivity (SC) and resting‐state functional connectivity (rsFC) networks undergo various changes in aging. To study these changes, we proposed a continuous dimension where at one end networks generalize well across age groups in… read more here.
Keywords: associated structural; age; age group; specificity ... See more keywords
Performance of SPINK1 and SPINK1-based diagnostic model in detection of hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.24025
Abstract: OBJECTIVES To identify the SPINK1 or SPINK1-based model as a more reliable biomarker for the diagnosis of hepatocellular carcinoma (HCC). METHODS Serum samples and related laboratory parameters were collected from 540 subjects (119 healthy donors, 113 patients… read more here.
Keywords: spink1 based; sensitivity; model; specificity ... See more keywords
Cell‐specific targeting of extracellular vesicles though engineering the glycocalyx
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12290
Abstract: Abstract Extracellular vesicles (EVs) are promising carriers for the delivery of a variety of chemical and biological drugs. However, their efficacy is limited by the lack of cellular specificity. Available methods to improve the tissue… read more here.
Keywords: extracellular vesicles; evs; specificity; glycocalyx ... See more keywords