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   Articles with "specificity" as a keyword



Pivotal Evaluation of an Artificial Intelligence System for Autonomous Detection of Referrable and Vision-Threatening Diabetic Retinopathy.

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recommendations! Published in 2021 at "JAMA network open"

DOI: 10.1001/jamanetworkopen.2021.34254

Abstract: Importance Diabetic retinopathy (DR) is a leading cause of blindness in adults worldwide. Early detection and intervention can prevent blindness; however, many patients do not receive their recommended annual diabetic eye examinations, primarily owing to… read more here.

Keywords: detection; diabetic retinopathy; system; sensitivity ... See more keywords

Sensitivity and Specificity of the Modified Checklist for Autism in Toddlers (Original and Revised): A Systematic Review and Meta-analysis.

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recommendations! Published in 2023 at "JAMA pediatrics"

DOI: 10.1001/jamapediatrics.2022.5975

Abstract: Importance The Modified Checklist for Autism in Toddlers (M-CHAT) and the M-CHAT, Revised With Follow-up (M-CHAT-R/F)-henceforth referred to as M-CHAT(-R/F)-are the most commonly used toddler screeners for autism spectrum disorder (ASD). Their use often differs… read more here.

Keywords: autism; sensitivity specificity; meta analysis; specificity ... See more keywords

IRE1α nucleotide sequence cleavage specificity in the unfolded protein response

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recommendations! Published in 2017 at "FEBS Letters"

DOI: 10.1002/1873-3468.12546

Abstract: Inositol‐requiring enzyme 1 (IRE1) is a conserved sensor of the unfolded protein response that has protein kinase and endoribonuclease (RNase) enzymatic activities and thereby initiates HAC1/XBP1 splicing. Previous studies demonstrated that human IRE1α (hIRE1α) does… read more here.

Keywords: cleavage; unfolded protein; protein response; cleavage specificity ... See more keywords

Specificity models in MAPK cascade signalling.

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recommendations! Published in 2023 at "FEBS open bio"

DOI: 10.1002/2211-5463.13619

Abstract: The precise execution of various cellular functions relies on the maintenance of signalling specificity from input detection to cellular outputs. However, diverse signalling pathways share similar or identical intermediate components. A well-conserved intermediate, the Mitogen-Activated… read more here.

Keywords: specificity models; mapk cascade; models mapk; specificity ... See more keywords

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202416331

Abstract: Derived from the bacterial immune system, CRISPR/Cas9 induces DSBs at specific DNA sequences, which are repaired by the cell's endogenous mechanisms, leading to gene insertions, deletions, or substitutions. Despite its transformative potential, several challenges remain… read more here.

Keywords: crispr cas; specificity; flexibility; accessibility ... See more keywords

Continental-scale interactions of Australian showy mistletoes and their hosts.

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recommendations! Published in 2024 at "American journal of botany"

DOI: 10.1002/ajb2.16443

Abstract: PREMISE Showy mistletoes are obligate hemiparasites of woody plants. Host specificity is therefore a fundamental determinant of mistletoe diversity, persistence, geographic distribution, and abundance. Investigations of host specificity in Australian Loranthaceae have focused mostly on… read more here.

Keywords: showy mistletoes; host; specificity; continental scale ... See more keywords

Switching the Cofactor Specificity of an Imine Reductase

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recommendations! Published in 2018 at "ChemCatChem"

DOI: 10.1002/cctc.201701194

Abstract: In the last years, imine reductases (IREDs) have gained importance for the formation of chiral amines by catalyzing asymmetric reductions of imines and chemo‐ and stereoselective reductive aminations. However, all characterized members of this steadily… read more here.

Keywords: imine reductase; cofactor specificity; switching cofactor; specificity imine ... See more keywords

Molecular allergy diagnosis is sensitive and avoids misdiagnosis in patients sensitized to seasonal allergens

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recommendations! Published in 2023 at "Clinical and Translational Allergy"

DOI: 10.1002/clt2.12231

Abstract: Abstract Background The specificity of extract‐based pollen allergy diagnosis is decreased due to cross‐reactivity via cross‐reactive carbohydrate determinants (CCDs) or panallergens such as profilins or polcalcins. This study aimed to explore the prevalence of sensitization… read more here.

Keywords: misdiagnosis; allergy diagnosis; diagnosis; pollen ... See more keywords

Leaf volatile and nonvolatile metabolites show different levels of specificity in response to herbivory

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recommendations! Published in 2023 at "Ecology and Evolution"

DOI: 10.1002/ece3.10123

Abstract: Abstract Plants produce diverse chemical defenses with contrasting effects on different insect herbivores. Deploying herbivore‐specific responses can help plants increase their defensive efficiency. Here, we explore how variation in induced plant responses correlates with herbivore… read more here.

Keywords: volatile nonvolatile; nonvolatile leaf; leaf; specificity ... See more keywords

Does combining an informant questionnaire with patient performance scales improve diagnostic test accuracy for cognitive impairment?

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recommendations! Published in 2017 at "International Journal of Geriatric Psychiatry"

DOI: 10.1002/gps.4647

Abstract: Cognitive screening instruments (CSIs) may be broadly divided into those testing patient performance and those questioning an informant for collateral history (Larner, 2017). The Alzheimer Association has recommended the combined use of an informant interview… read more here.

Keywords: cognitive impairment; series; performance; test ... See more keywords

Age‐specificity and generalization of behavior‐associated structural and functional networks and their relevance to behavioral domains

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recommendations! Published in 2022 at "Human Brain Mapping"

DOI: 10.1002/hbm.25759

Abstract: Behavior‐associated structural connectivity (SC) and resting‐state functional connectivity (rsFC) networks undergo various changes in aging. To study these changes, we proposed a continuous dimension where at one end networks generalize well across age groups in… read more here.

Keywords: associated structural; age; age group; specificity ... See more keywords