Precise and broad scope genome editing based on high-specificity Cas9 nickases
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DOI: 10.1093/nar/gkaa1236
Abstract: Abstract RNA-guided nucleases (RGNs) based on CRISPR systems permit installing short and large edits within eukaryotic genomes. However, precise genome editing is often hindered due to nuclease off-target activities and the multiple-copy character of the… read more here.
Keywords: genome editing; high specificity; specificity cas9; specificity ... See more keywords