Precise homology-directed installation of large genomic edits in human cells with cleaving and nicking high-specificity Cas9 variants
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DOI: 10.1093/nar/gkad165
Abstract: Abstract Homology-directed recombination (HDR) between donor constructs and acceptor genomic sequences cleaved by programmable nucleases, permits installing large genomic edits in mammalian cells in a precise fashion. Yet, next to precise gene knock-ins, programmable nucleases… read more here.
Keywords: crispr cas9; specificity crispr; cas9; high specificity ... See more keywords