Lipid specificity of the membrane binding domain of coagulation factor X
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13788
Abstract: Essentials Membrane‐binding GLA domains of coagulation factors are essential for proper clot formation. Factor X (FX) is specific to phosphatidylserine (PS) lipids through unknown atomic‐level interactions. Molecular dynamics simulations were used to develop the first… read more here.
Keywords: lipid specificity; coagulation; membrane binding; factor ... See more keywords
Oncogenic Ras Isoforms Signaling Specificity at the Membrane.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-2727
Abstract: How do Ras isoforms attain oncogenic specificity at the membrane? Oncogenic KRas, HRas, and NRas (K-Ras, H-Ras, and N-Ras) differentially populate distinct cancers. How they selectively activate effectors and why is KRas4B the most prevalent… read more here.
Keywords: oncogenic ras; specificity membrane; membrane; ras isoforms ... See more keywords