Dual‐specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27420
Abstract: The Ras/mitogen‐activated protein kinase (MAPK) pathway controls fundamental cellular processes such as proliferation, differentiation, and apoptosis. The dual‐specificity phosphatase 6 (DUSP6) regulates cytoplasmic MAPK signaling by dephosphorylating and inactivating extracellular signal‐regulated kinase (ERK1/2) MAPK. To… read more here.
Keywords: dual specificity; phosphatase; deletion; dusp6 ... See more keywords
Dual-specificity phosphatase 18 modulates the SUMOylation and aggregation of Ataxin-1.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.178
Abstract: We previously reported that SUMOylation promotes the aggregation of ataxin-1 and JNK is involved in the process. Here we show that dual-specificity phosphatase 18 (DUSP18), a member of protein tyrosine phosphatases, exerts the opposite effects… read more here.
Keywords: aggregation; dual specificity; ataxin; aggregation ataxin ... See more keywords
The role of dual‐specificity phosphatase 3 in melanocytic oncogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Dermatology"
DOI: 10.1111/exd.14653
Abstract: Dual‐specificity phosphatase 3 (DUSP3), also known as Vaccinia H1‐related phosphatase, is a protein tyrosine phosphatase that typically performs its major role in the regulation of multiple cellular functions through the dephosphorylation of its diverse and… read more here.
Keywords: melanocytic oncogenesis; phosphatase; dual specificity; oncogenesis ... See more keywords
Dual Specificity Phosphatase 3 (DUSP3) knockdown alleviates acute myocardial infarction damage via inhibiting apoptosis and inflammation
Sign Up to like & getrecommendations! Published in 2023 at "Current Neurovascular Research"
DOI: 10.2174/1567202620666230502115433
Abstract: Dual Specificity Phosphatase 3 (DUSP3) regulates the innate immune response and is associated with ischemia/reperfusion (I/R). However, the precise function of DUSP3 in acute myocardial infarction (AMI) remains to be established. In this study, the… read more here.
Keywords: apoptosis; dual specificity; phosphatase dusp3; dusp3 ... See more keywords
The Dual-Specificity Phosphatase 10 (DUSP10): Its Role in Cancer, Inflammation, and Immunity
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20071626
Abstract: Cancer is one of the most diagnosed diseases in developed countries. Inflammation is a common response to different stress situations including cancer and infection. In those processes, the family of mitogen-activated protein kinases (MAPKs) has… read more here.
Keywords: dual specificity; inflammation; role; cancer ... See more keywords