Specificity protein 1: Its role in colorectal cancer progression and metastasis.
Sign Up to like & getrecommendations! Published in 2017 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2017.02.024
Abstract: Specificity protein 1 (Sp1) is a widely expressed transcription factor that plays an important role in the promotion of oncogenes required for tumor survival, progression and metastasis. Sp1 is highly expressed in several cancers including… read more here.
Keywords: specificity protein; progression; progression metastasis; colorectal cancer ... See more keywords
Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy134
Abstract: Mutations in the lamin A/C gene (LMNA) encoding the nuclear intermediate filament proteins lamins A and C cause a group of tissue-selective diseases, the most common of which is dilated cardiomyopathy (herein referred to as… read more here.
Keywords: dual specificity; specificity protein; lmna cardiomyopathy; lamin gene ... See more keywords
Molecular characterization and nutritional regulation of specificity protein 1 (Sp1) in grass carp (Ctenopharyngodon idella)
Sign Up to like & getrecommendations! Published in 2018 at "Aquaculture Nutrition"
DOI: 10.1111/anu.12630
Abstract: Specificity protein 1 (Sp1) is a ubiquitous nuclear factor in eukaryotic cells and plays a crucial role in the regulation of di-/tripeptide absorption in the intestine. However, the function of Sp1 in bony fish remains… read more here.
Keywords: protein sp1; grass; specificity protein; grass carp ... See more keywords
Risk Factors for Esophageal Cancer, with an Emphasis on the Role of Specificity Protein Transcription Factors in Prognosis and Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Critical reviews in oncogenesis"
DOI: 10.1615/critrevoncog.2020036449
Abstract: Specificity protein (Sp) transcription factors regulate the expression of genes associated with several cellular processes and play a critical role in early development. Typically, Sp protein expression decreases with age in healthy adults. Research has… read more here.
Keywords: specificity protein; protein transcription; role; cancer ... See more keywords
Targeting dual specificity protein kinase TTK attenuates tumorigenesis of glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23152
Abstract: Accumulating evidence has proved that glioma stem-like cells (GSCs) are responsible for tumorigenesis, treatment resistance, and subsequent tumor recurrence in glioblastoma (GBM). In this study, we identified dual specificity protein kinase TTK (TTK) as the… read more here.
Keywords: dual specificity; glioblastoma; specificity protein; gbm ... See more keywords
Specificity Protein 1: A Protein With a Two-Sided Role in Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.757670
Abstract: Stroke is one of the leading causes of death and disability worldwide. However, there is a lack of effective medications to speed up the recovery process. Ischemic stroke, as the result of cerebral infarction or… read more here.
Keywords: ischemic stroke; specificity protein; role ischemic; stroke ... See more keywords
MicroRNA-376a inhibits cell proliferation and invasion in glioblastoma multiforme by directly targeting specificity protein 1
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.8089
Abstract: Glioblastoma multiforme (GBM), a World Health Organization grade IV glioma, is the most common and aggressive primary brain tumor in humans. microRNAs (miRNAs) are aberrantly expressed in numerous cancer types, including GBM. Abnormally expressed miRNAs… read more here.
Keywords: proliferation invasion; specificity protein; glioblastoma multiforme; proliferation ... See more keywords