Rational design, chemical synthesis and biological evaluation of novel biguanides exploring species-specificity responsiveness of TAAR1 agonists.
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DOI: 10.1016/j.ejmech.2018.01.059
Abstract: The design of novel chemical classes acting towards several G-protein-coupled receptors (GPCRs) represents a leading strategy in drug discovery, aimed at deriving effective and safe candidates for further assessment. During the last years, TAAR1 arose… read more here.
Keywords: species specificity; chemistry; chemical; specificity responsiveness ... See more keywords