Detection of ASC Speck Formation by Flow Cytometry and Chemical Cross-linking.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7519-8_10
Abstract: Assembly of a relatively large protein aggregate or "speck" formed by the adaptor protein ASC is a common downstream step in the activation of most inflammasomes. This unique feature of ASC allows its visualization by… read more here.
Keywords: asc speck; formation flow; speck formation; speck ... See more keywords
A new epiphyllous fly-speck fungus from the Early Cretaceous Potomac Group of Virginia (125–112 Ma): Protographum luttrellii, gen. et sp. nov.
Sign Up to like & getrecommendations! Published in 2020 at "Mycologia"
DOI: 10.1080/00275514.2020.1718441
Abstract: ABSTRACT Fly-speck fungi reproduce via thyriothecia that consist of sporogenous tissue appressed to cuticle surfaces of plant leaves and covered by a shield-like scutellum. Thyriothecial scutella likely evolved repeatedly in Dothideomycetes (Ascomycota), and their morphology… read more here.
Keywords: fly speck; 125 112; group virginia; potomac group ... See more keywords
Inflammasome activation in neutrophils of patients with severe COVID-19
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DOI: 10.1182/bloodadvances.2021005949
Abstract: Neutrophils with intact multilobulated nuclei show ASC speck formation and high histone H3 citrullination in patients with severe COVID-19. In murine neutrophils, ASC speck forms transiently at the microtubule organizing center, before nuclear rounding, early… read more here.
Keywords: activation; microscopy; asc speck; formation ... See more keywords
Apoptosis-associated speck-like protein containing a CARD-mediated release of matrix metalloproteinase 10 stimulates a change in microglia phenotype
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.976108
Abstract: Inflammation contributes to amyloid-β and tau pathology in Alzheimer’s disease (AD). Microglia facilitate an altered immune response that includes microgliosis, upregulation of inflammasome proteins, and elevation of matrix-metalloproteinases (MMPs). Studies of cerebrospinal fluid (CSF) and… read more here.
Keywords: speck like; release; speck; associated speck ... See more keywords
Molecular Characterization, Expression, and Regulatory Signal Pathway Analysis of Inflammasome Component Apoptosis-Associated Speck-like Protein Containing a CARD Domain (ASC) in Large Yellow Croaker (Larimichthys crocea)
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032175
Abstract: ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD)) is the only adaptor involved in the formation of multiple types of inflammasomes. Accumulating evidence demonstrates that ASC plays a critical role in the protection… read more here.
Keywords: card; expression; analysis; speck ... See more keywords