Erythroid spectrin binding modulates peroxidase and catalase activity of heme proteins.
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB life"
DOI: 10.1002/iub.2607
Abstract: Hemoglobin oxidation due to oxidative stress and disease conditions leads to generation of ROS (reactive oxygen species) and membrane attachment of hemoglobin in-vivo, where its redox activity leads to peroxidative damage of membrane lipids and… read more here.
Keywords: hemoglobin; spectrin; heme proteins; spectrin binding ... See more keywords
αI-spectrin represents evolutionary optimization of spectrin for red blood cell deformability.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.07.027
Abstract: Spectrin tetramers of the membranes of enucleated mammalian erythrocytes play a critical role in red blood cell survival in circulation. One of the spectrins, αI, emerged in mammals with enucleated red cells following duplication of… read more here.
Keywords: red blood; affinity; spectrin represents; blood cell ... See more keywords
Presentation of Early Heart Failure Phenotypes in βII-Spectrin Conditional Knockout Mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiac Failure"
DOI: 10.1016/j.cardfail.2019.07.321
Abstract: Background βII spectrin is an actin associated protein which regulates the localization of cytoskeletal and plasma membrane protein complexes necessary for normal cellular function. In cardiac myocytes βII spectrin recruits ankyrin-B to the cardiac dyad… read more here.
Keywords: spectrin; knockout; mice; heart failure ... See more keywords
Mechanical unfolding of spectrin reveals a super-exponential dependence of unfolding rate on force
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46525-w
Abstract: We investigated the mechanical unfolding of single spectrin molecules over a broad range of loading rates and thus unfolding forces by combining magnetic tweezers with atomic force microscopy. We find that the mean unfolding force… read more here.
Keywords: mechanical unfolding; rate force; force; rate ... See more keywords
Dynamics of the axon plasma membrane skeleton.
Sign Up to like & getrecommendations! Published in 2023 at "Soft matter"
DOI: 10.1039/d2sm01602h
Abstract: It was recently revealed via super-resolution microscopy experiments that the axon plasma membrane skeleton (APMS) comprises a series of periodically arranged azimuthal actin rings connected via longitudinal spectrin filaments forming an orthotropic network. The common… read more here.
Keywords: membrane skeleton; spectrin; extension; axon plasma ... See more keywords
The functional importance of lamins, actin, myosin, spectrin and the LINC complex in DNA repair
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Biology and Medicine"
DOI: 10.1177/1535370219876651
Abstract: Three major proteins in the nucleoskeleton, lamins, actin, and spectrin, play essential roles in maintenance of nuclear architecture and the integrity of the nuclear envelope, in mechanotransduction and mechanical coupling between the nucleoskeleton and cytoskeleton,… read more here.
Keywords: dna repair; lamins actin; spectrin; linc ... See more keywords
αII-spectrin in T cells is involved in the regulation of cell-cell contact leading to immunological synapse formation?
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0189545
Abstract: T-lymphocyte activation after antigen presentation to the T-Cell Receptor (TCR) is a critical step in the development of proper immune responses to infection and inflammation. This dynamic process involves reorganization of the actin cytoskeleton and… read more here.
Keywords: involved regulation; immunological synapse; formation; spectrin ... See more keywords
Severe Form of ßIV-Spectrin Deficiency With Mitochondrial Dysfunction and Cardiomyopathy—A Case Report
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2021.643805
Abstract: ßIV-spectrin is a protein of the spectrin family which is involved in the organization of the cytoskeleton structure and is found in high quantity in the axon initial segment and the nodes of Ranvier. Together… read more here.
Keywords: form spectrin; severe form; spectrin deficiency; mitochondrial dysfunction ... See more keywords
Progressive Ataxia, Memory Impairments, and Seizure Episodes in Spna2 R1098Q Mouse Variant Affecting Alpha II Spectrin’s Scaffold Stability
Sign Up to like & getrecommendations! Published in 2023 at "Brain Sciences"
DOI: 10.3390/brainsci13020261
Abstract: SPTAN1 spectrinopathies refer to a group of rare, inherited diseases associated with damage to non-erythrocytic α-II spectrin (α-II). They are linked to a range of mild to severe neuropathologies of the central and peripheral nervous… read more here.
Keywords: spectrin; scaffold stability; progressive ataxia; memory ... See more keywords