The use of online heart-cutting high-performance liquid chromatography coupled with linear ion trap mass spectrometry in the identification of impurities in vidarabine monophosphate.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of separation science"
DOI: 10.1002/jssc.201601320
Abstract: It is difficult to identify unknown impurities in nucleotide analogues by mass spectrometry because mass-spectrometry-incompatible mobile phases need to be used to separate the major ingredient from impurities. In this study, vidarabine monophosphate was selected,… read more here.
Keywords: spectrometry; mass spectrometry; liquid chromatography; high performance ... See more keywords
Strategies for analysis of isomeric peptides.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of separation science"
DOI: 10.1002/jssc.201700852
Abstract: This review presents an overview and recent progress of strategies for detecting isomerism in peptides, with focus on d/l epimerization and the various isomers that the presence of an aspartic acid residue may yield in… read more here.
Keywords: spectrometry; strategies analysis; mass; analysis isomeric ... See more keywords
Adding a new separation dimension to MS and LC-MS: What is the utility of ion mobility spectrometry?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of separation science"
DOI: 10.1002/jssc.201700919
Abstract: Ion mobility spectrometry is an analytical technique known for more than 100 years, which entails separating ions in the gas phase based on their size, shape, and charge. While ion mobility spectrometry alone can be… read more here.
Keywords: ion mobility; mobility spectrometry; spectrometry; mass spectrometry ... See more keywords
Evaluation and validation of an ion mobility quadrupole time-of-flight mass spectrometry pesticide screening approach.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of separation science"
DOI: 10.1002/jssc.201701059
Abstract: An ion mobility quadrupole time-of-flight mass spectrometry-based pesticide suspect screening methodology was developed and validated covering 20 plant-derived food matrices deriving from six commodity groups of different complexity according to the actual European Commission document… read more here.
Keywords: ion mobility; spectrometry; mass spectrometry;
Tissue sample preparations for preclinical research determined by molecular imaging mass spectrometry using MALDI.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202100578
Abstract: Matrix-assisted laser desorption/ionization - imaging mass spectrometry is an alternative tool, which can be implemented in order to obtain and visualize the "omic" signature of tissue samples. Its application to clinical study enables simultaneous imaging-based… read more here.
Keywords: mass spectrometry; spectrometry; imaging mass; research ... See more keywords
Ultra-fast screening of free fatty acids in human plasma using ion mobility mass spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200037
Abstract: Free fatty acids involved in many metabolic regulations in human body. In this work, an ultra-fast screening method was developed for the analysis of free fatty acids using trapped ion mobility spectrometry coupled with mass… read more here.
Keywords: free fatty; ultra fast; spectrometry; fast screening ... See more keywords
A multidimensional strategy to rapidly identify the chemical constituents in Shengxian Decoction by using ultra-performance liquid chromatography coupled with ion mobility spectrometry quadrupole time-of-flight mass spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200267
Abstract: As a well-known traditional Chinese medicine formula, the chemical constituents of Shengxian Decoction still remain unclear due to its complexity. In this study, a multidimensional strategy based on ultra-performance liquid chromatography coupled with ion mobility… read more here.
Keywords: spectrometry; strategy; shengxian decoction; medicine ... See more keywords
Advances in mass spectrometry‐based footprinting of membrane proteins
Sign Up to like & getrecommendations! Published in 2022 at "PROTEOMICS"
DOI: 10.1002/pmic.202100222
Abstract: Structural biology is entering an exciting time where many new high‐resolution structures of large complexes and membrane proteins (MPs) are determined regularly. These advances have been driven by over 15 years of technological improvements, first… read more here.
Keywords: membrane proteins; mass spectrometry; advances mass; based footprinting ... See more keywords
iBench: A ground truth approach for advanced validation of mass spectrometry identification method
Sign Up to like & getrecommendations! Published in 2022 at "Proteomics"
DOI: 10.1002/pmic.202200271
Abstract: The discovery of many noncanonical peptides detectable with sensitive mass spectrometry inside, outside, and on cells shepherded the development of novel methods for their identification, often not supported by a systematic benchmarking with other methods.… read more here.
Keywords: mass spectrometry; ground truth; spectrometry; identification ... See more keywords
Advanced mass spectrometry workflows for accurate quantification of trace-level host cell proteins in drug products: Benefits of FAIMS separation and gas-phase fractionation DIA.
Sign Up to like & getrecommendations! Published in 2023 at "Proteomics"
DOI: 10.1002/pmic.202300172
Abstract: Therapeutic monoclonal antibodies (mAb) production relies on multiple purification steps before release as a drug product (DP). A few host cell proteins (HCPs) may co-purify with the mAb. Their monitoring is crucial due to the… read more here.
Keywords: quantification; mass spectrometry; level; spectrometry ... See more keywords
Preliminary investigation of aluminium fluoride complexes in aqueous solutions with capillary electrophoresis coupled with electrospray ionization mass spectrometry and with inductively coupled plasma mass spectrometry
Sign Up to like & getrecommendations! Published in 2019 at "Rapid Communications in Mass Spectrometry"
DOI: 10.1002/rcm.8499
Abstract: RATIONALE It is crucial to identify and confirm the original species of aluminium ions (Al3+ ) dissolved in water, since they behave differently. Depending on their species, the toxicity differs. Capillary electrophoresis (CE) coupled with… read more here.
Keywords: spectrometry; capillary electrophoresis; coupled electrospray; mass spectrometry ... See more keywords