Native Mass Spectrometry for the Study of PROTAC GNE‐987‐Containing Ternary Complexes
Sign Up to like & getrecommendations! Published in 2021 at "Chemmedchem"
DOI: 10.1002/cmdc.202100113
Abstract: PROteolysis TArgeting Chimeras (PROTACs) promote the degradation, rather than inhibition, of a drug target as a mechanism for therapeutic treatment. Bifunctional PROTAC molecules allow simultaneous binding of both the target protein and an E3‐Ubiquitin ligase,… read more here.
Keywords: gne 987; native mass; ternary complexes; mass spectrometry ... See more keywords
Study on the impurity profiles of cloxacillin and flucloxacillin based on liquid chromatography tandem ion trap/time‐of‐flight mass spectrometry
Sign Up to like & getrecommendations! Published in 2024 at "Rapid Communications in Mass Spectrometry"
DOI: 10.1002/rcm.9840
Abstract: Cloxacillin and flucloxacillin are prone to degradation and polymerization in humid and hot environments, and their polymers have long been recognized to trigger allergic manifestations. A series of the degradation and polymerized impurities in cloxacillin… read more here.
Keywords: cloxacillin flucloxacillin; study impurity; mass spectrometry; impurity profiles ... See more keywords
Mass Spectrometry for the Study of Autism and Neurodevelopmental Disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-15950-4_28
Abstract: Mass spectrometry (MS) has been increasingly used to study central nervous system (CNS) disorders, including autism spectrum disorders (ASDs). The first studies of ASD using MS focused on the identification of external toxins, but current… read more here.
Keywords: autism; spectrometry study; mass spectrometry; neurodevelopmental disorders ... See more keywords