Use of Raman spectroscopy and size-exclusion chromatography coupled with HDX-MS spectroscopy for studying conformational changes of small proteins in solution.
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DOI: 10.1016/j.jpba.2020.113399
Abstract: Protein-based drugs are a relatively new paradigm in modern therapeutics. These large molecule drugs often have much higher specificity and selectivity compared to small molecules that have been used in therapeutics for centuries. However, there… read more here.
Keywords: spectroscopy size; exclusion chromatography; solution; spectroscopy ... See more keywords