Recent updates of fluoroquinolones as antibacterial agents
Sign Up to like & getrecommendations! Published in 2018 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201800141
Abstract: Fluoroquinolones remain one of the most important kind of antibacterial agents used nowadays. The emergence of more virulent and resistant strains of bacteria by the development of either mutated DNA‐binding proteins or efflux pump mechanism… read more here.
Keywords: antibacterial agents; recent updates; resistant strains; spectrum activity ... See more keywords
STA‐55, an Easily Accessible, Broad‐Spectrum, Activity‐Based Aldehyde Dehydrogenase Probe
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.201900771
Abstract: Aldehyde dehydrogenases (ALDHs) convert aldehydes into carboxylic acids and are often upregulated in cancer. They have been linked to therapy resistance and are therefore potential therapeutic targets. However, only a few selective and potent inhibitors… read more here.
Keywords: probe; activity based; spectrum activity; broad spectrum ... See more keywords
Structure-Based Rational Design of Small α-Helical Peptides with Broad-Spectrum Activity against Multidrug-Resistant Pathogens
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01708
Abstract: A series of small (7–12 mer) amphipathic cationic peptides were designed and synthesized to create short helical peptides with broad-range bactericidal activity and selectivity toward the bacterial cells. The analysis identified a lead 12-mer peptide… read more here.
Keywords: helical peptides; spectrum activity; peptides broad; activity ... See more keywords
Small Molecules Targeting the Flavivirus E Protein with Broad-Spectrum Activity and Antiviral Efficacy in Vivo.
Sign Up to like & getrecommendations! Published in 2019 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.8b00322
Abstract: Vaccines and antivirals to combat dengue, Zika, and other flavivirus pathogens present a major, unmet medical need. Vaccine development has been severely challenged by the antigenic diversity of these viruses and the propensity of non-neutralizing,… read more here.
Keywords: protein; activity; flavivirus; spectrum activity ... See more keywords
Spectrum Activity Surveillance: Modeling and Analysis From Perspectives of Surveillance Coverage and Culprit Detection
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Mobile Computing"
DOI: 10.1109/tmc.2020.3032434
Abstract: Spectrum activity surveillance (SAS) is essential to dynamic spectrum access (DSA)-enabled systems with a two-fold impact: it is a primitive mechanism to collect usage data for spectrum efficiency improvement; it is also a prime widget… read more here.
Keywords: activity surveillance; surveillance; coverage; spectrum ... See more keywords
Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR741
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00200-17
Abstract: ABSTRACT Novel approaches for the treatment of multidrug-resistant Gram-negative bacterial infections are urgently required. One approach is to potentiate the efficacy of existing antibiotics whose spectrum of activity is limited by the permeability barrier presented… read more here.
Keywords: spr741; gram negative; spectrum activity; potentiation ... See more keywords