The evolution of spectrum in antibiotics and bacteriocins
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205407119
Abstract: Significance Antibiotics, like penicillin, treat a wide range of infections. This broad-spectrum of activity has its evolutionary roots in microbial warfare, where antibiotics can provide a competitive edge. But bacteria also make narrow-spectrum toxins, which… read more here.
Keywords: spectrum toxins; evolution spectrum; broad spectrum; spectrum ... See more keywords
Evolving antibiotic spectrum
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214267119
Abstract: Microbes are capable of complex feats of social organization, working collectively to manipulate their local environment. When their local environment contains competing species or strains, the scene is set for microbial war, mediated by chemical… read more here.
Keywords: broad spectrum; spectrum; antibiotic spectrum; drug ... See more keywords
Modeling Likelihood of Coverage for Narrow Spectrum Antibiotics in Patients Hospitalized with Urinary Tract Infections
Sign Up to like & getrecommendations! Published in 2017 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofx163.632
Abstract: Abstract Background When prescribing empiric antibiotics, providers try to choose the narrowest spectrum antibiotic that will cover a patient’s infection. To do this they must assess the likelihood of coverage of different regimens. We developed… read more here.
Keywords: urinary tract; likelihood coverage; spectrum antibiotics; spectrum ... See more keywords
Changing Pattern of Antibiotics Usage Among Hospitalized Patients of a Tertiary Hospital in South Korea: 2004–2013
Sign Up to like & getrecommendations! Published in 2017 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofx163.772
Abstract: Abstract Background This study was performed to evaluate the changing pattern of antibiotics usage among hospitalized patients of tertiary hospital in South Korea. Methods Total antibiotics prescription record of hospitalized patients from 2004 to 2013… read more here.
Keywords: spectrum antibiotics; antibiotics usage; consumption; hospitalized patients ... See more keywords
The Dysbiosis Triggered by First-Line Tuberculosis Antibiotics Fails to Reduce Their Bioavailability
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DOI: 10.1128/mbio.00353-23
Abstract: Previous studies have shown that treatment of Mycobacterium tuberculosis infection with first-line antibiotics results in a long-lasting disruption of the host microbiota. Since the microbiome has been shown to influence the host availability of other… read more here.
Keywords: tuberculosis; dysbiosis; first line; spectrum antibiotics ... See more keywords
Long-term modification of gut microbiota by broad-spectrum antibiotics improves stroke outcome in rats
Sign Up to like & getrecommendations! Published in 2022 at "Stroke and Vascular Neurology"
DOI: 10.1136/svn-2021-001231
Abstract: Background The brain-gut axis is a major regulator of the central nervous system. We investigated the effects of treatment with broad-spectrum antibiotics on gut and brain inflammation, infarct size and long-term behavioral outcome after cerebral… read more here.
Keywords: long term; gut; microbiota; broad spectrum ... See more keywords
The Mystery of Futility of Appropriate Antibiotics for Coinfection in COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202107-1656le
Abstract: We read with great interest the article by Rouze and colleagues about comparing early bacterial identification between mechanically ventilated coronavirus disease (COVID-19) and influenza (1). We want to congratulate the authors for their dedication to… read more here.
Keywords: infection; rouze colleagues; spectrum antibiotics; coinfection ... See more keywords
Physicians under Pressure: Evidence from Antibiotics Prescribing in England
Sign Up to like & getrecommendations! Published in 2022 at "Medical Decision Making"
DOI: 10.1177/0272989x211069931
Abstract: Background Many physicians are experiencing increasing demands from both their patients and society. Evidence is scarce on the consequences of the pressure on physicians’ decision making. We present a theoretical framework and predict that increasing… read more here.
Keywords: different sources; spectrum antibiotics; pressure; evidence ... See more keywords
A roadmap for designing narrow-spectrum antibiotics targeting bacterial pathogens
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Cell"
DOI: 10.15698/mic2022.07.780
Abstract: Clostridioides difficile (Cdiff) infection (CDI) continues to be the leading threat of nosocomial deaths worldwide and a major burden on health-care systems. Broad-spectrum antibiotics eradicate the normal gut microbiome, killing protective commensal bacteria and increasing… read more here.
Keywords: narrow spectrum; designing narrow; spectrum; bacterial pathogens ... See more keywords
The Response of the Rodent Gut Microbiome to Broad-Spectrum Antibiotics Is Different in Males and Females
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.897283
Abstract: Gut microbiome composition is different in males and females, but sex is rarely considered when prescribing antibiotics, and sex-based differences in gut microbiome recovery following antibiotic treatment are poorly understood. Here, we compared the effects… read more here.
Keywords: exposed males; broad spectrum; gut microbiome; males females ... See more keywords
Under-utilization of Narrow-Spectrum Antibiotics in the Ambulatory Management of Pediatric UTI: A Single-Center Experience
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2021.675759
Abstract: Objective: There are urinary tract infection (UTI) guidelines for treatment of patients read more here.
Keywords: narrow spectrum; pediatric uti; spectrum antibiotics; management pediatric ... See more keywords