Broad‐Spectrum Antifungal Agents: Fluorinated Aryl‐ and Heteroaryl‐Substituted Hydrazones
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DOI: 10.1002/cmdc.202000626
Abstract: Fluorinated aryl‐ and heteroaryl‐substituted monohydrazones displayed excellent broad‐spectrum activity against various fungal strains, including a panel of clinically relevant Candida auris strains relative to a control antifungal agent, voriconazole (VRC). These monohydrazones displayed less hemolysis… read more here.
Keywords: spectrum antifungal; fluorinated aryl; heteroaryl substituted; aryl heteroaryl ... See more keywords
Novel Triazoles with Potent and Broad-Spectrum Antifungal Activity In Vitro and In Vivo.
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DOI: 10.1021/acs.jmedchem.3c00266
Abstract: Triazoles have demonstrated significant efficacy in the treatment of fungal infections. However, increasing drug resistance is a growing concern that negatively impacts their effectiveness. By designing a well-crafted side chain, triazoles can be endowed with… read more here.
Keywords: antifungal activity; novel triazoles; triazoles potent; spectrum antifungal ... See more keywords
Mycogenic Selenium Nanoparticles as Potential New Generation Broad Spectrum Antifungal Molecules †
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DOI: 10.3390/biom9090419
Abstract: The current challenges of sustainable agricultural development augmented by global climate change have led to the exploration of new technologies like nanotechnology, which has potential in providing novel and improved solutions. Nanotools in the form… read more here.
Keywords: mycogenic selenium; microscopy; spectrum antifungal; spectroscopy ... See more keywords